Jia Yukun, Li Yan
Department of Endocrinology, Tangshan Gongren Hospital, Tangshan, 063000, China.
Open Life Sci. 2024 Oct 29;19(1):20220945. doi: 10.1515/biol-2022-0945. eCollection 2024.
To explore the impact of score in patients with diabetes peripheral neuropathy (DPN) treated with traditional Chinese medicine package (TCMP) plus red light therapy and lipoic acid on malondialdehyde (MDA), erythrocyte superoxide dismutase (SOD), total antioxidant capacity (TAOC), motor nerve conduction velocity (MNCV), sensory nerve conduction velocity (SNCV), and Toronto Clinical Scoring System (TSS). A total of 108 patients with DPN hospitalized in the hospital were chosen and divided into groups with the random number table. In the control group (CG) 54 patients were treated with conventional lipoic acid, and 54 patients in the experimental group (EG) accepted TCMP plus red light on the basis of the CG. The MDA, SOD, TAOC, MNCV, SNCV, and TSS scores before treatment and after treatment were compared between the two groups. Before treatment, there was no statistically significant difference in the levels of oxidation indicators, nerve conduction velocity, and symptom scores between the two groups ( > 0.05). After treatment, the MDA in the EG was lower than that in the CG, with a statistical significance difference ( < 0.05). The SOD and TAOC in the EG were higher than those in the CG, and the difference was statistically significant ( < 0.05). The MNCV and SNCV of median nerve, common peroneal nerve, and tibial nerve in the EG were significantly higher than those in the CG ( < 0.05). The TSS score of the EG was lower than that of the CG, and the difference was statistically significant ( < 0.05). The treatment of patients with DPN with lipoic acid plus TCMP and red light therapy can improve the symptoms and signs of disease, promote the recovery of motor and sensory conduction velocity, and optimize the body oxidation indicators.
探讨中药方剂（TCMP）联合红光疗法及硫辛酸治疗糖尿病周围神经病变（DPN）患者对丙二醛（MDA）、红细胞超氧化物歧化酶（SOD）、总抗氧化能力（TAOC）、运动神经传导速度（MNCV）、感觉神经传导速度（SNCV）及多伦多临床评分系统（TSS）的影响。选取该院收治的108例DPN患者，采用随机数字表法分组。对照组（CG）54例患者采用常规硫辛酸治疗，实验组（EG）54例患者在CG基础上接受TCMP联合红光治疗。比较两组治疗前后的MDA、SOD、TAOC、MNCV、SNCV及TSS评分。治疗前，两组氧化指标、神经传导速度及症状评分水平比较，差异无统计学意义（>0.05）。治疗后，EG组MDA低于CG组，差异有统计学意义（<0.05）。EG组SOD和TAOC高于CG组，差异有统计学意义（<0.05）。EG组正中神经、腓总神经及胫神经的MNCV和SNCV均显著高于CG组（<0.05）。EG组TSS评分低于CG组，差异有统计学意义（<0.05）。硫辛酸联合TCMP及红光疗法治疗DPN患者可改善疾病症状和体征，促进运动和感觉传导速度恢复，优化机体氧化指标。
