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ANO1 表达在癌症中的预后意义。

Prognostic significance of ANO1 expression in cancers.

机构信息

Qingdao University School of Pharmacy, Department of Pharmacology.

Qingdao Sixth People's Hospital, Department of Gastroenterology.

出版信息

Medicine (Baltimore). 2021 Jan 29;100(4):e24525. doi: 10.1097/MD.0000000000024525.

DOI:10.1097/MD.0000000000024525
PMID:33530281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7850693/
Abstract

BACKGROUND

Anoctamin-1 (ANO1) plays a pivotal role in cancer progression. A meta-analysis was conducted to assess the potential prognostic role of ANO1 in cancers.

METHODS

A total of 1760 patients from 7 eligible studies were included into the analysis. Pooled hazard ratios or odds ratios were extracted and calculated with a random-effects model, and analyses of heterogeneity bias were conducted.

RESULTS

Our results showed that over expression of ANO1 was significantly correlated with poor overall survival in all cancers (HR = 1.52; 95% CI: 1.19-1.92; P = .0006). Subgroup analysis indicated that there was a significant association between over expression of ANO1 and poor prognosis breast cancer (HR = 3.24; 95% CI: 1.74-6.04), head and neck squamous cell carcinoma (HR = 1.14; 95% CI: 1.00-1.30), esophageal squamous cell carcinoma (HR = 1.93; 95% CI: 1.07-3.50), gastric cancer (HR = 1.62; 95% CI: 1.12-2.34) and colorectal cancer (HR = 1.38; 95% CI: 1.03-1.85). In addition, over expression of ANO1 was not associated with TNM stage, histological grade, lymph node metastasis, tumor size, age and gender. However, ANO1 was significantly associated with human epidermal growth factor receptor 2, but not associated with progesterone receptor or estrogen receptor in breast cancer.

CONCLUSIONS

Our results indicate that ANO1 can be a predictive factor for prognosis of cancer.

摘要

背景

Anoctamin-1（ANO1）在癌症进展中起着关键作用。进行了荟萃分析以评估 ANO1 在癌症中的潜在预后作用。

方法

共有 7 项合格研究中的 1760 名患者纳入分析。使用随机效应模型提取并计算了合并的风险比或优势比，并进行了异质性偏倚分析。

结果

我们的结果表明，ANO1 的过表达与所有癌症的总生存期不良显著相关（HR=1.52；95%CI：1.19-1.92；P=0.0006）。亚组分析表明，ANO1 的过表达与乳腺癌（HR=3.24；95%CI：1.74-6.04）、头颈部鳞状细胞癌（HR=1.14；95%CI：1.00-1.30）、食管鳞状细胞癌（HR=1.93；95%CI：1.07-3.50）、胃癌（HR=1.62；95%CI：1.12-2.34）和结直肠癌（HR=1.38；95%CI：1.03-1.85）的不良预后存在显著相关性。此外，ANO1 的过表达与 TNM 分期、组织学分级、淋巴结转移、肿瘤大小、年龄和性别无关。然而，ANO1 与乳腺癌中的人类表皮生长因子受体 2 显著相关，但与孕激素受体或雌激素受体无关。

结论

我们的结果表明，ANO1 可以作为癌症预后的预测因子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dea/7850693/c17f173cf6eb/medi-100-e24525-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dea/7850693/545131487202/medi-100-e24525-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dea/7850693/f49506b4fbb3/medi-100-e24525-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dea/7850693/f69c5cb586ae/medi-100-e24525-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dea/7850693/1aacc3c690c4/medi-100-e24525-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dea/7850693/c17f173cf6eb/medi-100-e24525-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dea/7850693/545131487202/medi-100-e24525-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dea/7850693/f49506b4fbb3/medi-100-e24525-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dea/7850693/f69c5cb586ae/medi-100-e24525-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dea/7850693/1aacc3c690c4/medi-100-e24525-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dea/7850693/c17f173cf6eb/medi-100-e24525-g005.jpg

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