Department of Food Science and Human Nutrition, Faculty of Agriculture, Setsunan University, 45-1 Nagaotouge-cho, Hirakata, Osaka 573-0101, Japan .
Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan.
Int J Mol Sci. 2021 Jan 26;22(3):1200. doi: 10.3390/ijms22031200.
Atherosclerotic disease, such as coronary artery disease (CAD), is known to be a chronic inflammatory disease, as well as an age-related disease. Excessive oxidative stress produced by reactive oxygen species (ROS) contributes to the pathogenesis of atherosclerosis. Sestrin2 is an anti-oxidant protein that is induced by various stresses such as hypoxia, DNA damage, and oxidative stress. Sestrin2 is also suggested to be associated with aging. Sestrin2 is expressed and secreted mainly by macrophages, endothelial cells, and cardiomyocytes. Sestrin2 plays an important role in suppressing the production and accumulation of ROS, thus protecting cells from oxidative damage. Since sestrin2 is reported to have anti-oxidant and anti-inflammatory properties, it may play a protective role against the progression of atherosclerosis and may be a potential therapeutic target for the amelioration of atherosclerosis. Regarding the association between blood sestrin2 levels and atherosclerotic disease, the blood sestrin2 levels in patients with CAD or carotid atherosclerosis were reported to be high. High blood sestrin2 levels in patients with such atherosclerotic disease may reflect a compensatory response to increased oxidative stress and may help protect against the progression of atherosclerosis. This review describes the protective role of sestrin2 against the progression of atherosclerotic and cardiac diseases.
动脉粥样硬化疾病，如冠心病（CAD），已知是一种慢性炎症性疾病，也是一种与年龄相关的疾病。活性氧（ROS）产生的过度氧化应激有助于动脉粥样硬化的发病机制。Sestrin2 是一种抗氧化蛋白，可被缺氧、DNA 损伤和氧化应激等各种应激诱导。Sestrin2 也与衰老有关。Sestrin2 主要由巨噬细胞、内皮细胞和心肌细胞表达和分泌。Sestrin2 在抑制 ROS 的产生和积累方面发挥重要作用，从而保护细胞免受氧化损伤。由于 sestrin2 具有抗氧化和抗炎特性，它可能对动脉粥样硬化的进展起保护作用，并且可能是改善动脉粥样硬化的潜在治疗靶点。关于血液 sestrin2 水平与动脉粥样硬化疾病的关系，据报道 CAD 或颈动脉粥样硬化患者的血液 sestrin2 水平较高。此类动脉粥样硬化疾病患者的高血液 sestrin2 水平可能反映了对增加的氧化应激的补偿反应，并可能有助于防止动脉粥样硬化的进展。本综述描述了 sestrin2 对动脉粥样硬化和心脏疾病进展的保护作用。
