Kishimoto Yoshimi, Saita Emi, Ohmori Reiko, Kondo Kazuo, Momiyama Yukihiko
Endowed Research Department "Food for Health", Ochanomizu University, Tokyo, Japan.
Faculty of Regional Design, Utsunomiya University, Tochigi, Japan.
Clin Chim Acta. 2020 May;504:56-59. doi: 10.1016/j.cca.2020.01.020. Epub 2020 Jan 23.
Sestrin2 is a stress-inducible antioxidant protein that plays a protective role against oxidative stress. However, blood sestrin2 concentrations in subjects with carotid atherosclerosis have not been elucidated.
We investigated plasma sestrin2 concentrations in 152 subjects undergoing carotid ultrasonography. Plaque severity was evaluated as plaque score.
Of the 152 subjects, plaque was found in 63 (41%). Plasma sestrin2 concentrations were higher in 63 subjects with plaque than in 89 without plaque (median 14.1 vs. 12.8 ng/ml, P < 0.02). A stepwise increase in sestrin2 concentrations was found depending on plaque score: 12.8 ng/ml in score = 0 (n = 89), 12.7 ng/ml in score = 1 (n = 31), and 15.9 ng/ml in score ≥2 (n = 32)(P < 0.005). Especially, sestrin2 concentrations in subjects with score ≥ 2 were higher than in score = 0 and score = 1 (P < 0.05). Sestrin2 concentrations correlated with plaque score (r = 0.24, P < 0.005). In multivariate analysis, sestrin2 concentration was an independent factor associated with score ≥ 2. Odds ratio for score ≥ 2 was 5.70 (95%CI = 1.99-16.35) for high sestrin2 concentration (>13.0 ng/ml).
Plasma sestrin2 concentrations were found to be high in subjects with carotid plaque and to be associated with plaque severity. High plasma sestrin2 concentrations in subjects with carotid plaque may reflect a protective response against the progression of carotid atherosclerosis.
硒蛋白2是一种应激诱导的抗氧化蛋白，对氧化应激起保护作用。然而，颈动脉粥样硬化患者的血液硒蛋白2浓度尚未阐明。
我们调查了152名接受颈动脉超声检查的受试者的血浆硒蛋白2浓度。将斑块严重程度评估为斑块评分。
152名受试者中，63人（41%）发现有斑块。63名有斑块的受试者的血浆硒蛋白2浓度高于89名无斑块的受试者（中位数分别为14.1 ng/ml和12.8 ng/ml，P < 0.02）。根据斑块评分发现硒蛋白2浓度呈逐步升高：评分为0（n = 89）时为12.8 ng/ml，评分为1（n = 31）时为12.7 ng/ml，评分≥2（n = 32）时为15.9 ng/ml（P < 0.005）。特别是，评分≥2的受试者的硒蛋白2浓度高于评分为0和评分为1的受试者（P < 0.05）。硒蛋白2浓度与斑块评分相关（r = 0.24，P < 0.005）。在多变量分析中，硒蛋白2浓度是与评分≥2相关的独立因素。高硒蛋白2浓度（>13.0 ng/ml）时，评分≥2的比值比为5.70（95%CI = 1.99 - 16.35）。
发现颈动脉斑块患者的血浆硒蛋白2浓度较高，且与斑块严重程度相关。颈动脉斑块患者血浆硒蛋白2浓度高可能反映了对颈动脉粥样硬化进展的一种保护反应。
