Experimental Cardiology, Department of Internal Medicine I, Justus Liebig University, Aulweg 129, 35392 Giessen, Germany.
Department of Cardiology, Kerckhoff Clinic GmbH, 61231 Bad Nauheim, Germany.
Int J Mol Sci. 2021 Jan 26;22(3):1207. doi: 10.3390/ijms22031207.
Increased vascular permeability is a hallmark of several cardiovascular anomalies, including ischaemia/reperfusion injury and inflammation. During both ischaemia/reperfusion and inflammation, massive amounts of various nucleotides, particularly adenosine 5'-triphosphate (ATP) and adenosine, are released that can induce a plethora of signalling pathways via activation of several purinergic receptors and may affect endothelial barrier properties. The nature of the effects on endothelial barrier function may depend on the prevalence and type of purinergic receptors activated in a particular tissue. In this review, we discuss the influence of the activation of various purinergic receptors and downstream signalling pathways on vascular permeability during pathological conditions.
血管通透性增加是几种心血管异常的标志，包括缺血/再灌注损伤和炎症。在缺血/再灌注和炎症过程中，会释放大量的各种核苷酸，特别是腺苷 5'-三磷酸 (ATP) 和腺苷，这些核苷酸可以通过激活几种嘌呤能受体诱导大量的信号通路，可能影响内皮屏障特性。对内皮屏障功能的影响性质可能取决于在特定组织中激活的嘌呤能受体的流行程度和类型。在这篇综述中，我们讨论了在病理条件下各种嘌呤能受体的激活及其下游信号通路对血管通透性的影响。
