• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

微纤维相关蛋白 4 调节应激诱导的心脏重构。

Microfibrillar-Associated Protein 4 Regulates Stress-Induced Cardiac Remodeling.

机构信息

Physiology and Cell Biology (L.E.D., W.L., J.M.P., M.S.S., P.M.L.J., P.J.M., F.A.), The Ohio State University Wexner Medical Center, Columbus.

Biomedical Engineering, The Ohio State University, Columbus (X.X., T.J.H.).

出版信息

Circ Res. 2021 Mar 19;128(6):723-737. doi: 10.1161/CIRCRESAHA.120.317146. Epub 2021 Feb 3.

DOI:10.1161/CIRCRESAHA.120.317146
PMID:33530700
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8188624/
Abstract

[Figure: see text].

摘要

[图：见正文]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/8188624/cf3ab8b04861/nihms-1672881-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/8188624/ff97bb8ef09a/nihms-1672881-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/8188624/a8f4cfff76bb/nihms-1672881-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/8188624/a1f08d41b92e/nihms-1672881-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/8188624/0949ff409ca5/nihms-1672881-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/8188624/b1a4e352176f/nihms-1672881-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/8188624/0a1dde73e32a/nihms-1672881-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/8188624/cf3ab8b04861/nihms-1672881-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/8188624/ff97bb8ef09a/nihms-1672881-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/8188624/a8f4cfff76bb/nihms-1672881-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/8188624/a1f08d41b92e/nihms-1672881-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/8188624/0949ff409ca5/nihms-1672881-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/8188624/b1a4e352176f/nihms-1672881-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/8188624/0a1dde73e32a/nihms-1672881-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/8188624/cf3ab8b04861/nihms-1672881-f0007.jpg

相似文献

1
Microfibrillar-Associated Protein 4 Regulates Stress-Induced Cardiac Remodeling.微纤维相关蛋白 4 调节应激诱导的心脏重构。
Circ Res. 2021 Mar 19;128(6):723-737. doi: 10.1161/CIRCRESAHA.120.317146. Epub 2021 Feb 3.
2
Deletion of Microfibrillar-Associated Protein 4 Attenuates Left Ventricular Remodeling and Dysfunction in Heart Failure.微纤维相关蛋白 4 的缺失可减轻心力衰竭中的左心室重构和功能障碍。
J Am Heart Assoc. 2020 Sep;9(17):e015307. doi: 10.1161/JAHA.119.015307. Epub 2020 Aug 28.
3
Plasminogen Activator Inhibitor Type I Controls Cardiomyocyte Transforming Growth Factor-β and Cardiac Fibrosis.I型纤溶酶原激活物抑制剂调控心肌细胞转化生长因子-β及心脏纤维化。
Circulation. 2017 Aug 15;136(7):664-679. doi: 10.1161/CIRCULATIONAHA.117.028145. Epub 2017 Jun 6.
4
Integrin binding angiopoietin-1 monomers reduce cardiac hypertrophy.整合素结合血管生成素-1单体可减轻心肌肥大。
FASEB J. 2008 Aug;22(8):3010-23. doi: 10.1096/fj.07-100966. Epub 2008 May 23.
5
MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation.MFAP4促进血管平滑肌迁移、增殖并加速新生内膜形成。
Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):122-33. doi: 10.1161/ATVBAHA.115.306672. Epub 2015 Nov 12.
6
Syndecan-4 deficiency accelerates the transition from compensated hypertrophy to heart failure following pressure overload.Syndecan-4缺乏会加速压力超负荷后从代偿性肥大向心力衰竭的转变。
Cardiovasc Pathol. 2017 May-Jun;28:74-79. doi: 10.1016/j.carpath.2017.03.008. Epub 2017 Mar 30.
7
Miro2 Regulates Inter-Mitochondrial Communication in the Heart and Protects Against TAC-Induced Cardiac Dysfunction.Miro2 调节心脏中线粒体间通讯并防止 TAC 诱导的心脏功能障碍。
Circ Res. 2019 Sep 27;125(8):728-743. doi: 10.1161/CIRCRESAHA.119.315432. Epub 2019 Aug 28.
8
MG53, A Novel Regulator of KChIP2 and I, Plays a Critical Role in Electrophysiological Remodeling in Cardiac Hypertrophy.MG53，一种新型的 KChIP2 和 I 的调节因子，在心脏肥厚中的电生理重构中发挥关键作用。
Circulation. 2019 Apr 30;139(18):2142-2156. doi: 10.1161/CIRCULATIONAHA.118.029413.
9
Microfibrillar-associated protein 4 in health and disease.微纤维相关蛋白 4 在健康和疾病中的作用。
Matrix Biol. 2022 Aug;111:1-25. doi: 10.1016/j.matbio.2022.05.008. Epub 2022 May 26.
10
Adapter molecule DOC-2 is differentially expressed in pressure and volume overload hypertrophy and inhibits collagen synthesis in cardiac fibroblasts.衔接分子DOC-2在压力超负荷和容量超负荷肥大中差异表达，并抑制心脏成纤维细胞中的胶原蛋白合成。
J Appl Physiol (1985). 2007 May;102(5):2024-32. doi: 10.1152/japplphysiol.00924.2006. Epub 2007 Jan 25.

引用本文的文献

1
Identification of biomarkers and immune microenvironment associated with heart failure through bioinformatics and machine learning.通过生物信息学和机器学习识别与心力衰竭相关的生物标志物和免疫微环境。
Front Mol Biosci. 2025 May 8;12:1580880. doi: 10.3389/fmolb.2025.1580880. eCollection 2025.
2
Prognostic Significance and Biologic Associations of Senescence-Associated Secretory Phenotype Biomarkers in Heart Failure.衰老相关分泌表型生物标志物在心力衰竭中的预后意义及生物学相关性。
J Am Heart Assoc. 2024 Sep 3;13(17):e033675. doi: 10.1161/JAHA.123.033675. Epub 2024 Aug 29.
3
Research progress of autophagy in heart failure.

本文引用的文献

1
Single-Cell Reconstruction of Progression Trajectory Reveals Intervention Principles in Pathological Cardiac Hypertrophy.单细胞重建进展轨迹揭示病理性心脏肥大的干预原则。
Circulation. 2020 May 26;141(21):1704-1719. doi: 10.1161/CIRCULATIONAHA.119.043053. Epub 2020 Feb 26.
2
The Role of the TGF-β Superfamily in Myocardial Infarction.转化生长因子-β超家族在心肌梗死中的作用
Front Cardiovasc Med. 2019 Sep 18;6:140. doi: 10.3389/fcvm.2019.00140. eCollection 2019.
3
Identification of differentially expressed genes and preliminary validations in cardiac pathological remodeling induced by transverse aortic constriction.
自噬在心力衰竭中的研究进展
Am J Transl Res. 2024 May 15;16(5):1991-2000. doi: 10.62347/OBXQ9477. eCollection 2024.
4
Identifying as a Biomarker Covering Multiple Pathogenic Pathways for Diagnosing Heart Failure: From Machine Learning to Mechanism Interpretation.鉴定作为一种生物标志物，涵盖多种心力衰竭发病机制的诊断：从机器学习到机制阐释。
Biomolecules. 2024 Feb 2;14(2):179. doi: 10.3390/biom14020179.
5
Triptolide attenuates cardiac remodeling by inhibiting pyroptosis and EndMT via modulating USP14/Keap1/Nrf2 pathway.雷公藤甲素通过调节USP14/Keap1/Nrf2信号通路抑制细胞焦亡和内皮-间质转化，从而减轻心脏重塑。
Heliyon. 2024 Jan 3;10(2):e24010. doi: 10.1016/j.heliyon.2024.e24010. eCollection 2024 Jan 30.
6
Single-cell RNA sequencing reveals the transcriptional heterogeneity of Tbx18-positive cardiac cells during heart development.单细胞 RNA 测序揭示了 Tbx18 阳性心脏细胞在心脏发育过程中的转录异质性。
Funct Integr Genomics. 2024 Jan 24;24(1):18. doi: 10.1007/s10142-024-01290-6.
7
Large scale plasma proteomics identifies novel proteins and protein networks associated with heart failure development.大规模血浆蛋白质组学鉴定出与心力衰竭发展相关的新型蛋白质和蛋白质网络。
Nat Commun. 2024 Jan 15;15(1):528. doi: 10.1038/s41467-023-44680-3.
8
Development and validation of risk prediction and neural network models for dilated cardiomyopathy based on WGCNA.基于加权基因共表达网络分析（WGCNA）的扩张型心肌病风险预测及神经网络模型的开发与验证
Front Med (Lausanne). 2023 Oct 5;10:1239056. doi: 10.3389/fmed.2023.1239056. eCollection 2023.
9
Identification of immune-related genes for the diagnosis of ischemic heart failure based on bioinformatics.基于生物信息学的缺血性心力衰竭诊断免疫相关基因的鉴定
iScience. 2023 Oct 4;26(11):108121. doi: 10.1016/j.isci.2023.108121. eCollection 2023 Nov 17.
10
The secretome atlas of two mouse models of progeria.两种早衰症小鼠模型的分泌组图谱。
Aging Cell. 2023 Oct;22(10):e13952. doi: 10.1111/acel.13952. Epub 2023 Aug 10.
横断主动脉缩窄诱导的心脏病理性重构中差异表达基因的鉴定及初步验证。
Int J Mol Med. 2019 Oct;44(4):1447-1461. doi: 10.3892/ijmm.2019.4291. Epub 2019 Jul 30.
4
The N-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy.N6-甲基腺苷 mRNA 甲基转移酶 METTL3 控制心脏稳态和肥大。
Circulation. 2019 Jan 22;139(4):533-545. doi: 10.1161/CIRCULATIONAHA.118.036146.
5
CTGF/CCN2 is an autocrine regulator of cardiac fibrosis.CTGF/CCN2 是心脏纤维化的自分泌调节剂。
J Mol Cell Cardiol. 2018 Aug;121:205-211. doi: 10.1016/j.yjmcc.2018.07.130. Epub 2018 Jul 21.
6
Analyzing gene expression profiles with preliminary validations in cardiac hypertrophy induced by pressure overload.在压力超负荷诱导的心肌肥大中进行初步验证，分析基因表达谱。
Can J Physiol Pharmacol. 2018 Aug;96(8):701-709. doi: 10.1139/cjpp-2017-0585. Epub 2018 Mar 6.
7
Fibroblast-specific TGF-β-Smad2/3 signaling underlies cardiac fibrosis.成纤维细胞特异性转化生长因子-β- Smad2/3信号传导是心脏纤维化的基础。
J Clin Invest. 2017 Oct 2;127(10):3770-3783. doi: 10.1172/JCI94753. Epub 2017 Sep 11.
8
TGF-β1 affects cell-cell adhesion in the heart in an NCAM1-dependent mechanism.TGF-β1 通过一种依赖于 NCAM1 的机制影响心脏中的细胞-细胞黏附。
J Mol Cell Cardiol. 2017 Nov;112:49-57. doi: 10.1016/j.yjmcc.2017.08.015. Epub 2017 Sep 1.
9
The extracellular matrix in myocardial injury, repair, and remodeling.心肌损伤、修复与重塑中的细胞外基质
J Clin Invest. 2017 May 1;127(5):1600-1612. doi: 10.1172/JCI87491.
10
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.新型β-内酰胺衍生物调节 RGD 结合和白细胞整合素介导的细胞黏附和信号转导。
J Med Chem. 2016 Nov 10;59(21):9721-9742. doi: 10.1021/acs.jmedchem.6b00576. Epub 2016 Oct 21.