Department of Pharmacy, East West University, Dhaka, Bangladesh.
Department of Pharmacy, Southeast University, Dhaka, Bangladesh.
Curr Drug Metab. 2021;22(7):550-560. doi: 10.2174/1389200222666210202110129.
Parkinson's disease (PD) is a progressive neurodegenerative disorder that exerts a huge burden on our society. The occurrence of this neurodegenerative disease has been increasing day-by-day. PD can be a serious concern if the patients are left untreated. However, conventional treatment has many side-effects and less bioavailability in the brain. Therefore, the necessary measurement is required to solve the limitations of PD treatment. Nanotechnology has made a major contribution to comprehend PD pathogenesis. Nanotechnology can provide efficient therapies that have reduced side-effects and increased bioavailability in the brain. This review emphasizes the emerging promise of nanoparticle-based treatment, drug delivery, and other therapeutic approaches for PD. Besides, the advantages of different approaches on nanotechnology platforms are far better over conventional therapy in the treatment of PD.
帕金森病(PD)是一种进行性神经退行性疾病,给我们的社会带来了巨大的负担。这种神经退行性疾病的发病率日益增加。如果患者得不到治疗,PD 可能会成为一个严重的问题。然而,传统的治疗方法有许多副作用,而且在大脑中的生物利用度较低。因此,需要采取必要的措施来解决 PD 治疗的局限性。纳米技术为理解 PD 的发病机制做出了重大贡献。纳米技术可以提供有效的治疗方法,减少副作用,提高大脑中的生物利用度。本文综述了基于纳米粒子的治疗、药物传递和其他治疗方法在 PD 中的新进展。此外,纳米技术平台上的不同方法在治疗 PD 方面的优势远远优于传统疗法。