Dey Rajib Kumar, Hilmy Abdullah Isneen, Imad Hisham Ahmed, Yoosuf Abdul Azeez, Latheef Ali Abdulla
Department of Internal Medicine, Indira Gandhi Memorial Hospital, Male', Maldives.
Mahidol-Osaka Center for Infectious Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
J Med Case Rep. 2021 Feb 2;15(1):57. doi: 10.1186/s13256-020-02659-4.
Maldives reported its first Coronavirus disease 2019 (COVID-19) case on March 7th, 2020. Since then more than 9400 positive cases and 33 deaths have been reported. Recently studies have shown that COVID-19 patients with diabetes had a poor prognosis and a higher mortality rate when compared to the non-diabetic patients. Poorly controlled diabetic patients had a higher incidence of complications like diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) which might have been precipitated by COVID-19. DKA and HHS are potentially lethal but preventable conditions. During this pandemic, although cases of uncontrolled diabetes are frequently reported, there is scarcity in reporting of cases with diabetic emergencies.
Case 1 was a 53-year old Asian male, admitted on Day 10th of illness with DKA with acute kidney injury, and Moderate COVID-19. Case 2 was a 72-year old Asian male, admitted with mild COVID-19 who developed HHS with acute kidney injury on day 9 of illness. Both patients were managed conservatively in intensive care unit, with intravenous fluids and insulin.
Clinicians should focus on close monitoring of diabetic patients with COVID-19, to prevent diabetic emergencies like DKA and HHS. It is important to aggressively manage these conditions for a favorable outcome.
马尔代夫于2020年3月7日报告了首例2019冠状病毒病(COVID-19)病例。自那时以来,已报告了9400多例阳性病例和33例死亡。最近的研究表明,与非糖尿病患者相比,COVID-19糖尿病患者预后较差,死亡率较高。血糖控制不佳的糖尿病患者发生糖尿病酮症酸中毒(DKA)和高渗高血糖状态(HHS)等并发症的发生率较高,这些并发症可能由COVID-19诱发。DKA和HHS是潜在致命但可预防的疾病。在这次大流行期间,虽然经常报告未控制的糖尿病病例,但糖尿病急症病例的报告却很少。
病例1是一名53岁的亚洲男性,在发病第10天因DKA伴急性肾损伤及中度COVID-19入院。病例2是一名72岁的亚洲男性,因轻度COVID-19入院,在发病第9天出现HHS伴急性肾损伤。两名患者均在重症监护病房接受保守治疗,给予静脉输液和胰岛素治疗。
临床医生应密切关注COVID-19糖尿病患者,以预防DKA和HHS等糖尿病急症。积极治疗这些疾病以获得良好结局很重要。