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Single-dose intraoperative radiotherapy during lumpectomy for breast cancer: an innovative patient-centred treatment.乳腺癌保乳术中单次剂量放疗：一种创新的以患者为中心的治疗方法。
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2
Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial.保乳术后单次剂量靶向术中放疗（TARGIT-IORT）治疗早期乳腺癌的长期生存和局部控制结果：TARGIT-A 随机临床试验。
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3
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Environmental and social benefits of the targeted intraoperative radiotherapy for breast cancer: data from UK TARGIT-A trial centres and two UK NHS hospitals offering TARGIT IORT.乳腺癌靶向术中放疗的环境和社会效益：来自英国TARGIT-A试验中心及两家提供TARGIT术中放疗的英国国民健康服务体系（NHS）医院的数据。
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An international randomised controlled trial to compare TARGeted Intraoperative radioTherapy (TARGIT) with conventional postoperative radiotherapy after breast-conserving surgery for women with early-stage breast cancer (the TARGIT-A trial).一项国际随机对照试验，旨在比较早期乳腺癌女性保乳手术后靶向术中放疗（TARGIT）与传统术后放疗（TARGIT-A试验）。
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New clinical and biological insights from the international TARGIT-A randomised trial of targeted intraoperative radiotherapy during lumpectomy for breast cancer.国际 TARGIT-A 临床试验：保乳术中靶向术中放疗的新临床和生物学见解
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ndocrine therapy with accelerated artial breast irradiatin or exclusive ultra-accelerated artial breast irradiation for women aged ≥ 60 years with arly-stage breast cancer (EPOPE): The rationale for a GEC-ESTRO randomized phase III-controlled trial.内分泌治疗联合加速部分乳腺照射或单纯超加速部分乳腺照射用于≥60岁早期乳腺癌女性（EPOPE）：一项GEC-ESTRO随机III期对照试验的理论依据
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Accelerated Partial-Breast Irradiation Compared With Whole-Breast Irradiation for Early Breast Cancer: Long-Term Results of the Randomized Phase III APBI-IMRT-Florence Trial.加速部分乳房照射与全乳房照射治疗早期乳腺癌的比较：APBI-IMRT-Florence 随机 III 期试验的长期结果。
J Clin Oncol. 2020 Dec 10;38(35):4175-4183. doi: 10.1200/JCO.20.00650. Epub 2020 Aug 24.
2
Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial.保乳术后单次剂量靶向术中放疗（TARGIT-IORT）治疗早期乳腺癌的长期生存和局部控制结果：TARGIT-A 随机临床试验。
BMJ. 2020 Aug 19;370:m2836. doi: 10.1136/bmj.m2836.
3
Targeted Intraoperative Radiotherapy for Early Breast Cancer-Reply.早期乳腺癌的术中靶向放射治疗——回复
JAMA Oncol. 2020 Oct 1;6(10):1637-1638. doi: 10.1001/jamaoncol.2020.2730.
4
Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward): 5-year efficacy and late normal tissue effects results from a multicentre, non-inferiority, randomised, phase 3 trial.每周 1 周与 3 周（FAST-Forward）的分割式乳房放射治疗：来自多中心、非劣效性、随机、3 期试验的 5 年疗效和晚期正常组织效应结果。
Lancet. 2020 May 23;395(10237):1613-1626. doi: 10.1016/S0140-6736(20)30932-6. Epub 2020 Apr 28.
5
Comparison of Toxicity and Cosmetic Outcomes After Accelerated Partial Breast Irradiation or Whole Breast Irradiation Using 3-Dimensional Conformal External Beam Radiation Therapy.使用三维适形外照射放疗进行加速部分乳腺照射或全乳照射后毒性和美容效果的比较。
Adv Radiat Oncol. 2019 Sep 27;5(2):171-179. doi: 10.1016/j.adro.2019.09.005. eCollection 2020 Mar-Apr.
6
Effect of Delayed Targeted Intraoperative Radiotherapy vs Whole-Breast Radiotherapy on Local Recurrence and Survival: Long-term Results From the TARGIT-A Randomized Clinical Trial in Early Breast Cancer.延迟靶向术中放疗与全乳放疗对局部复发和生存的影响：早期乳腺癌 TARGIT-A 随机临床试验的长期结果。
JAMA Oncol. 2020 Jul 1;6(7):e200249. doi: 10.1001/jamaoncol.2020.0249. Epub 2020 Jul 9.
7
Nationwide prevalence and trends of acute cardiovascular and cerebrovascular events among adult breast cancer survivors with a history of radiation therapy.有放射治疗史的成年乳腺癌幸存者中急性心血管和脑血管事件的全国患病率及趋势
Breast Cancer Res Treat. 2020 Feb;180(1):267-268. doi: 10.1007/s10549-020-05535-3. Epub 2020 Jan 22.
8
Long-term primary results of accelerated partial breast irradiation after breast-conserving surgery for early-stage breast cancer: a randomised, phase 3, equivalence trial.早期乳腺癌保乳手术后加速部分乳房照射的长期主要结果：一项随机、3 期、等效性试验。
Lancet. 2019 Dec 14;394(10215):2155-2164. doi: 10.1016/S0140-6736(19)32514-0. Epub 2019 Dec 5.
9
External beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node-negative breast cancer (RAPID): a randomised controlled trial.保乳手术后局部晚期导管原位癌和淋巴结阴性乳腺癌患者行体外加速部分乳房照射与全乳房照射的对比（RAPID）：一项随机对照试验。
Lancet. 2019 Dec 14;394(10215):2165-2172. doi: 10.1016/S0140-6736(19)32515-2. Epub 2019 Dec 5.
10
Cosmetic outcome as rated by patients, doctors, nurses and BCCT.core software assessed over 5 years in a subset of patients in the TARGIT-A Trial.患者、医生、护士和 BCCT.core 软件在 TARGIT-A 试验的亚组患者中评估超过 5 年的美容效果。
Radiat Oncol. 2018 Apr 13;13(1):68. doi: 10.1186/s13014-018-0998-x.

乳腺癌保乳术中单次剂量放疗：一种创新的以患者为中心的治疗方法。

Single-dose intraoperative radiotherapy during lumpectomy for breast cancer: an innovative patient-centred treatment.

机构信息

Division of Surgery and Interventional Science, University College London, London, UK.

Department of Biostatistics, University of Notre Dame, Fremantle, WA, Australia.

出版信息

Br J Cancer. 2021 Apr;124(9):1469-1474. doi: 10.1038/s41416-020-01233-5. Epub 2021 Feb 2.

DOI:10.1038/s41416-020-01233-5
PMID:33531693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7851812/
Abstract

In the randomised TARGIT-A trial, risk-adapted targeted intraoperative radiotherapy (TARGIT-IORT) during lumpectomy was non-inferior to whole-breast external beam radiotherapy, for local recurrence. In the long-term, no difference was found in any breast cancer outcome, whereas there were fewer deaths from non-breast-cancer causes. TARGIT-IORT should be included in pre-operative consultations with eligible patients.

摘要

在随机 TARGIT-A 试验中，保乳手术后风险适应的靶向术中放疗（TARGIT-IORT）在局部复发方面不劣于全乳外照射放疗。长期来看，任何乳腺癌结局均无差异，而非乳腺癌原因导致的死亡人数更少。TARGIT-IORT 应纳入适合患者的术前咨询中。