Pombo-Suarez Manuel, Maneiro Fernandez Jose Ramon, Gomez-Reino Juan Jesus
Rheumatology Service, Complejo Hospitalario Universitario, Santiago de Compostela, Spain.
Rheumatology Service, Complejo Hospitalario Universitario, Pontevedra, Spain.
Patient Prefer Adherence. 2021 Jan 26;15:111-117. doi: 10.2147/PPA.S291983. eCollection 2021.
To evaluate adherence to treatment in a cohort of patients with rheumatoid arthritis in Spain and to identify potential predictors of adherence.
An observational, cross-sectional, multicenter study in outpatient clinics of Rheumatology Departments from 41 centers was conducted. A validated Spanish version of the compliance questionnaire in Rheumatology was used to measure adherence in a cohort of patients with rheumatoid arthritis, representative of the Spanish population. Univariate and multivariate analyses were performed to detect predictors of adherence.
A total of 859 patients were recruited. An adherence rate of 79% was established. No differences were detected in adherence in patients receiving biologic disease-modifying antirheumatic drugs compared to conventional disease-modifying antirheumatic drugs, in patients receiving intravenous therapies compared to other routes of administration and in patients treated in specific day hospitals compared to polyvalent day hospitals. The number of drugs and cohabitation were independent predictors of adherence.
An inexpensive and useful method was used to measure adherence in Spanish population. The adherence rate in rheumatoid arthritis is still suboptimal. Simpler, more convenient dosing regimens may improve compliance. Increased knowledge of compliance in patients with rheumatoid arthritis and the identification of possible predictors of adherence will allow to develop effective intervention strategies.
评估西班牙类风湿关节炎患者队列的治疗依从性，并确定依从性的潜在预测因素。
在41个中心的风湿病科门诊进行了一项观察性、横断面、多中心研究。使用经过验证的西班牙语版风湿病依从性问卷，对一组代表西班牙人群的类风湿关节炎患者的依从性进行测量。进行单因素和多因素分析以检测依从性的预测因素。
共招募了859名患者。确定的依从率为79%。与接受传统改善病情抗风湿药物的患者相比，接受生物改善病情抗风湿药物的患者在依从性方面未检测到差异；与接受其他给药途径的患者相比，接受静脉治疗的患者在依从性方面未检测到差异；与综合日间医院的患者相比，在特定日间医院接受治疗的患者在依从性方面未检测到差异。药物数量和同居情况是依从性的独立预测因素。
使用了一种廉价且有用的方法来测量西班牙人群的依从性。类风湿关节炎的依从率仍未达到最佳水平。更简单、更方便的给药方案可能会提高依从性。增加类风湿关节炎患者对依从性的认识并确定可能的依从性预测因素，将有助于制定有效的干预策略。
