Bovbjerg Pernille, Høgh Ditte, Froberg Lonnie, Schmal Hagen, Kassem Moustapha
Department of Orthopedic Surgery, Odense University Hospital, Odense, Denmark.
Department of Orthopedic Surgery, Hospital of Southern Denmark, Odense, Denmark.
EFORT Open Rev. 2021 Jan 4;6(1):9-14. doi: 10.1302/2058-5241.6.200029. eCollection 2021 Jan.
The aging of our society is associated with an increasing number of insufficiency fractures of the pelvis and the current standard of care is pain control and early mobilization. The aim of this study was to explore whether parathyroid hormone (PTH) treatment can support bone healing in these patients.We conducted a systematic review searching the databases PubMed, Embase and Cochrane. Our primary outcome was fracture healing, secondary outcome measures comprised pain, mobility and patient-reported outcome measures (PROMs).Eight articles were included in the qualitative synthesis, of which two were included in a meta-analysis. However, only three studies were comparative including one randomized controlled trial. Fracture healing and reported pain were assessed after eight weeks, and were significantly improved in the group being treated with PTH (p < 0.01) in the meta-analysis. All articles described a positive effect for PTH on fracture healing and pain.Our systematic review indicates that there is a positive effect of PTH treatment on healing and pain in patients with insufficiency fracture in the pelvic ring, but further research is necessary. Cite this article: 2021;6:9-14. DOI: 10.1302/2058-5241.6.200029.
我们社会的老龄化与骨盆不全骨折数量的增加相关，目前的护理标准是疼痛控制和早期活动。本研究的目的是探讨甲状旁腺激素（PTH）治疗是否能促进这些患者的骨愈合。我们进行了一项系统评价，检索了PubMed、Embase和Cochrane数据库。我们的主要结局是骨折愈合，次要结局指标包括疼痛、活动能力和患者报告结局指标（PROMs）。八项文章被纳入定性综合分析，其中两项被纳入荟萃分析。然而，只有三项研究是比较性的，包括一项随机对照试验。在荟萃分析中，八周后评估骨折愈合情况和报告的疼痛，接受PTH治疗的组有显著改善（p < 0.01）。所有文章均描述了PTH对骨折愈合和疼痛有积极作用。我们的系统评价表明，PTH治疗对骨盆环不全骨折患者的愈合和疼痛有积极作用，但仍需进一步研究。引用本文：2021；6：9 - 14。DOI：10.1302/2058 - 5241.6.200029。
