Na Woong Chae, Lee Sang Hong, Jung Sung, Jang Hyun Woong, Jo Suenghwan
Department of Orthopaedic Surgery, College of Medicine, Chosun University, Gwangju, Korea.
Hip Pelvis. 2017 Jun;29(2):120-126. doi: 10.5371/hp.2017.29.2.120. Epub 2017 Jun 2.
To evaluate clinical features and the effect of parathyroid hormone (PTH) on treatment outcomes of patients with pelvic insufficiency fractures.
Fifteen patients diagnosed with pelvic insufficiency fractures were evaluated retrospectively. All patients had osteoporosis with mean lumbar T score of -3.9 (range, -3.1 to -6.4) and the mean age was 76.5 years. In all cases, simple radiography and computed tomography was used for final diagnosis; additional magnetic resonance imaging and technetium bone scans were used to confirm the diagnosis in 2 and 6 patients, respectively. Initial conservative treatment was used in all cases; treatment with PTH was applied in 5 cases. Radiological follow-up was done every 4 weeks up to 6 months and every 3 months thereafter. Symptom improvement was measured using visual analogue scale (VAS) score.
Fractures were located: i) sacrum and pubis (9 cases), ii) isolated sacrum (4 cases) and iii) isolated pubis (2 cases). One case showed fracture displacement and pain aggravation at 4 week follow-up which was treated with percutaneous sacro-iliac fixation using cannulated screws. Duration of bone union was significantly shorter in the patients who used PTH (<0.05). VAS scores were also lower in the group treated with PTH; however, statistical significance was not reached.
In patients with osteoporosis, a pelvic insufficiency fracture should be considered if pain is experienced in the pelvic area in the absence of major trauma. While nonoperatic has been shown to be sufficient for treatment, our study shows that PTH therapy shortens treatment period and could be a favorable treatment option.
评估骨盆不全性骨折患者的临床特征以及甲状旁腺激素(PTH)对治疗效果的影响。
回顾性评估15例诊断为骨盆不全性骨折的患者。所有患者均患有骨质疏松症,腰椎平均T值为-3.9(范围为-3.1至-6.4),平均年龄为76.5岁。所有病例均采用简单的X线摄影和计算机断层扫描进行最终诊断;分别有2例和6例患者使用了额外的磁共振成像和锝骨扫描来确诊。所有病例均采用初始保守治疗;5例患者应用了PTH治疗。在6个月内每4周进行一次影像学随访,此后每3个月进行一次。使用视觉模拟量表(VAS)评分来衡量症状改善情况。
骨折部位如下:i)骶骨和耻骨(9例),ii)孤立的骶骨(4例)和iii)孤立的耻骨(2例)。1例患者在4周随访时出现骨折移位和疼痛加重,采用空心螺钉经皮骶髂固定治疗。使用PTH的患者骨愈合时间明显缩短(<0.05)。接受PTH治疗的组VAS评分也较低;然而,未达到统计学意义。
对于骨质疏松症患者,如果在无重大创伤的情况下骨盆区域出现疼痛,应考虑骨盆不全性骨折。虽然已证明非手术治疗足以治愈,但我们的研究表明,PTH治疗可缩短治疗时间,可能是一种有利的治疗选择。