Hernández Vargas Juliana Alexandra, Ramírez Barbosa Paula Ximena, Valbuena-Garcia Ana María, Acuña Lizbeth, González-Diaz Jaime A
Epidemiologist at Cuenta de Alto Costo, Fondo Colombiano de Enfermedades de Alto Costo, Bogotá, Colombia.
Analytics specialist at Cuenta de Alto Costo, Fondo Colombiano de Enfermedades de Alto Costo, Bogotá, Colombia.
Gynecol Oncol Rep. 2021 Jan 7;35:100697. doi: 10.1016/j.gore.2021.100697. eCollection 2021 Feb.
Cervical cancer (CC) is one of the leading causes of morbidity in upper-middle income countries such as Colombia. Several studies have reported poor prognosis when treatment is delayed. We aimed to describe the factors associated with delays in time to treatment initiation (TTI) in Colombian women with CC. Cross-sectional analysis including newly diagnosed cases of CC during 2018 and reported to the National Administrative Cancer Registry. TTI was defined as days from diagnosis to the first treatment (chemotherapy, radiation, or surgery). Linear and multinomial logistic regression models were estimated to analyze the association of interest. 1,249 new cases of CC were analyzed (26.98% and 40.11% locally advanced). The median age was 46 years (IQR: 36-58). Median TTI was 71 days (IQR: 42-105), varying from 70 days (IQR: 43-106) among the surgery group to 76 days (IQR: 41-118) in women under chemotherapy. Only 12.41% were treated within 30 days from diagnosis. TTI was significantly longer in women with state insurance (β = 18.95 days, 95% CI: 11.77-26.13) compared with those insured by the third payer. Women from the Pacific and Eastern regions also had a significantly longer TTI than those living in the capital of Colombia. Age, health insurance, region of residence, and stage at diagnosis were associated with TTI longer than 45 days in the multinomial model. We concluded that demographic variables (age, region of residence, and health insurance) which are proxies of social disparities and poor access to quality health care services, were associated with delays in TTI.
宫颈癌(CC)是哥伦比亚等中高收入国家发病的主要原因之一。多项研究报告称,治疗延迟会导致预后不良。我们旨在描述哥伦比亚宫颈癌女性患者治疗开始时间(TTI)延迟的相关因素。横断面分析纳入了2018年新诊断的宫颈癌病例,并上报至国家癌症管理登记处。TTI定义为从诊断到首次治疗(化疗、放疗或手术)的天数。采用线性和多项逻辑回归模型来分析感兴趣的关联。分析了1249例宫颈癌新病例(26.98%为局部晚期,40.11%为局部晚期)。中位年龄为46岁(四分位间距:36 - 58岁)。中位TTI为71天(四分位间距:42 - 105天),手术组为70天(四分位间距:43 - 106天),化疗女性患者为76天(四分位间距:41 - 118天)。仅12.41%的患者在诊断后30天内接受治疗。与第三方支付保险的女性相比,参加国家保险的女性TTI显著更长(β = 18.95天,95%置信区间:11.77 - 26.13)。来自太平洋和东部地区的女性TTI也显著长于居住在哥伦比亚首都的女性。在多项模型中,年龄、医疗保险、居住地区和诊断分期与TTI超过45天相关。我们得出结论,作为社会差距和获得优质医疗服务机会少的代表的人口统计学变量(年龄、居住地区和医疗保险)与TTI延迟相关。