一种双管齐下的光动力纳米药物，用于预防基底样乳腺癌的转移。
A two-pronged photodynamic nanodrug to prevent metastasis of basal-like breast cancer.
机构信息
Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
出版信息
Chem Commun (Camb). 2021 Mar 2;57(18):2305-2308. doi: 10.1039/d0cc08162k.
A two-pronged concept combining photodynamic therapy (PDT) and epithelial-mesenchymal transition (EMT) blockade in a minimalist nanoplatform was proposed to combat basal-like breast cancer (BLBC) metastasis. Based on PDT-mediated tumor killing and epalrestat (Epa)-mediated EMT blockade, as-prepared Ce6/Epa nanoparticles prevented BLBC metastasis effectively in vivo, providing a very promising two-pronged strategy against BLBC metastasis.
提出了一种两管齐下的概念，即将光动力疗法 (PDT) 和上皮-间充质转化 (EMT) 阻断结合在一个极简纳米平台中，以对抗基底样乳腺癌 (BLBC) 的转移。基于 PDT 介导的肿瘤杀伤和依帕司他 (Epa) 介导的 EMT 阻断，所制备的 Ce6/Epa 纳米颗粒在体内有效地预防了 BLBC 的转移，为对抗 BLBC 转移提供了一种很有前途的两管齐下的策略。
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