College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310032, P. R. China.
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310032, P. R. China and State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, The Chinese Academy of Sciences, Lanzhou 730000, P. R. China.
Chem Commun (Camb). 2021 Mar 2;57(18):2273-2276. doi: 10.1039/d0cc07743g.
A nickel-catalyzed reductive decyanation of aromatic nitriles has been developed, in which the readily available and abundant ethanol was applied as the hydride donor. Various functional groups on the aromatic rings, such as alkoxyl, amino, imino and amide, were compatible in this catalytic protocol. Heteroaryl, benzylic and alkenyl nitriles were also tolerated. Mechanistic investigation indicated that ethanol provided hydride efficiently via β-hydride elimination in this reductive decyanation.
发展了一种镍催化的芳基腈的还原脱氰反应，其中使用易得且丰富的乙醇作为氢供体。在这个催化体系中，芳环上的各种官能团，如烷氧基、氨基、亚氨基和酰胺基等，都是相容的。杂芳基、苄基和烯基腈也能耐受。机理研究表明，在这种还原脱氰反应中，乙醇通过β-氢消除有效地提供了氢。
