Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, HCI, 8093, Zürich, Switzerland.
Chemistry. 2021 Aug 16;27(46):11823-11826. doi: 10.1002/chem.202101273. Epub 2021 Jul 7.
A nickel-catalyzed thiolation of aryl nitriles has been developed to access functionalized aryl thioethers. The ligand dcype (1,2-bis(dicyclohexylphosphino)ethane) as well as the base KO Bu (potassium tert-butoxide) are essential to achieve this transformation. This scalable and practical process involves both a C-C bond activation and a C-S bond formation. Furthermore, this reaction shows a high functional-group tolerance and enables the late-stage functionalization of important molecules.
镍催化芳基腈的硫代反应已经被开发出来，以获得功能化的芳基硫醚。配体 dcype（1,2-双（二环己基膦基）乙烷）以及碱 KO Bu（叔丁醇钾）对于实现这种转化是必不可少的。这个可扩展且实用的过程涉及 C-C 键的活化和 C-S 键的形成。此外，该反应对官能团具有高耐受性，并能够实现重要分子的后期官能化。
