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Nitric oxide and COVID-19: Dose, timing and how to administer it might be crucial.

作者信息

Frostell Claes G, Hedenstierna Göran

机构信息

Department of Anaesthesia and Intensive Care, Karolinska Institutet at Danderyd Hospital, Stockholm, Sweden.

Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.

出版信息

Acta Anaesthesiol Scand. 2021 May;65(5):576-577. doi: 10.1111/aas.13788. Epub 2021 Mar 6.

DOI:10.1111/aas.13788
PMID:33533477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8013843/
Abstract
摘要

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本文引用的文献

1
Effects of inhaled nitric oxide in COVID-19-induced ARDS - Is it worthwhile?吸入一氧化氮治疗 COVID-19 诱导的 ARDS 的效果如何——是否值得？
Acta Anaesthesiol Scand. 2021 May;65(5):629-632. doi: 10.1111/aas.13757. Epub 2020 Dec 20.
2
Mitigation of the replication of SARS-CoV-2 by nitric oxide in vitro.一氧化氮对 SARS-CoV-2 体外复制的抑制作用。
Redox Biol. 2020 Oct;37:101734. doi: 10.1016/j.redox.2020.101734. Epub 2020 Sep 21.
3
High Concentrations of Nitric Oxide Inhalation Therapy in Pregnant Patients With Severe Coronavirus Disease 2019 (COVID-19).高浓度一氧化氮吸入疗法治疗重症 2019 冠状病毒病（COVID-19）孕妇。
Obstet Gynecol. 2020 Dec;136(6):1109-1113. doi: 10.1097/AOG.0000000000004128.
4
Nitric oxide dosed in short bursts at high concentrations may protect against Covid 19.高浓度短时间内给予一氧化氮可能有助于预防新冠病毒 19（Covid-19）。
Nitric Oxide. 2020 Oct 1;103:1-3. doi: 10.1016/j.niox.2020.06.005. Epub 2020 Jun 23.
5
Inhaled nitric oxide does not reduce mortality in patients with acute respiratory distress syndrome regardless of severity: systematic review and meta-analysis.吸入一氧化氮并不能降低急性呼吸窘迫综合征患者的死亡率，无论疾病严重程度如何：系统评价和荟萃分析。
Crit Care Med. 2014 Feb;42(2):404-12. doi: 10.1097/CCM.0b013e3182a27909.
6
Nitric oxide up-regulates the glucocorticoid receptor and blunts the inflammatory reaction in porcine endotoxin sepsis.一氧化氮上调猪内毒素血症中的糖皮质激素受体并减轻炎症反应。
Crit Care Med. 2007 Jan;35(1):26-32. doi: 10.1097/01.CCM.0000250319.91575.BB.
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Time-course and dose-response of nitric oxide inhalation for systemic oxygenation and pulmonary hypertension in patients with adult respiratory distress syndrome.一氧化氮吸入对成人呼吸窘迫综合征患者全身氧合及肺动脉高压的时间进程和剂量反应
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