Zhao Yifan, Li Cheng, Zhang Shuai, Cheng Jiayu, Liu Yucheng, Han Xiaorong, Wang Yinghui, Wang Yonggang
Department of Cardiovascular Center, The First Hospital of Jilin University, Changchun, China.
Department of Family and Community Medicine, Feinberg School of Medicine, McGaw Medical Center of Northwestern University, Chicago, IL, United States.
Front Microbiol. 2023 Oct 2;14:1277552. doi: 10.3389/fmicb.2023.1277552. eCollection 2023.
Nitric oxide (NO), as an important gaseous medium, plays a pivotal role in the human body, such as maintaining vascular homeostasis, regulating immune-inflammatory responses, inhibiting platelet aggregation, and inhibiting leukocyte adhesion. In recent years, the rapid prevalence of coronavirus disease 2019 (COVID-19) has greatly affected the daily lives and physical and mental health of people all over the world, and the therapeutic efficacy and resuscitation strategies for critically ill patients need to be further improved and perfected. Inhaled nitric oxide (iNO) is a selective pulmonary vasodilator, and some studies have demonstrated its potential therapeutic use for COVID-19, severe respiratory distress syndrome, pulmonary infections, and pulmonary hypertension. In this article, we describe the biochemistry and basic characteristics of NO and discuss whether iNO can act as a "savior" for COVID-19 and related respiratory and cardiovascular disorders to exert a potent clinical protective effect.
一氧化氮（NO）作为一种重要的气体介质，在人体中发挥着关键作用，如维持血管稳态、调节免疫炎症反应、抑制血小板聚集以及抑制白细胞黏附。近年来，2019冠状病毒病（COVID-19）的迅速流行极大地影响了全世界人们的日常生活以及身心健康，危重症患者的治疗效果和复苏策略有待进一步改进和完善。吸入一氧化氮（iNO）是一种选择性肺血管扩张剂，一些研究已证明其在治疗COVID-19、严重呼吸窘迫综合征、肺部感染及肺动脉高压方面具有潜在的治疗用途。在本文中，我们描述了NO的生物化学及基本特性，并探讨iNO是否能作为COVID-19及相关呼吸和心血管疾病的“救星”发挥强大的临床保护作用。
