Nordal K P, Dahl E, Thomassen Y, Brodwall E K, Halse J
Medical Department B, National Hospital, Oslo, Norway.
Pharmacol Toxicol. 1988 Feb;62(2):80-3. doi: 10.1111/j.1600-0773.1988.tb01850.x.
During 1984 and 1985 we performed frequent measurements of serum aluminum (Al) in patients with moderate chronic renal failure, and healthy controls, all living in the Oslo region. The results demonstrated seasonal variations with high levels in the autumn. During the peak periods serum Al increased by a factor greater than four. Outside the peaks patients using Al-containing phosphate binders had higher serum Al levels than non-users, a difference not seen during the peaks. Serum Al levels were unrelated to parathyroid hormone (PTH) concentrations and to calcitriol intake. Urinary excretion and the glomerular filtration rate was stable during the period with high serum Al in the autumn 1984. Increased gastrointestinal absorption of Al, possibly caused by a waterborne factor with chelating properties, may explain the seasonal variations.
1984年至1985年期间，我们对所有居住在奥斯陆地区的中度慢性肾衰竭患者和健康对照者进行了血清铝（Al）的频繁测量。结果显示存在季节性变化，秋季水平较高。在高峰期，血清铝增加了四倍多。在高峰期之外，使用含铝磷结合剂的患者血清铝水平高于未使用者，而在高峰期未观察到这种差异。血清铝水平与甲状旁腺激素（PTH）浓度和骨化三醇摄入量无关。1984年秋季血清铝水平较高期间，尿排泄和肾小球滤过率稳定。胃肠道对铝的吸收增加，可能是由具有螯合特性的水性因子引起的，这可能解释了季节性变化。
