Hackländer T, Szabó Z, Vosberg H, Feinendegen L E
Department of Nuclear Medicine, University of Düsseldorf, Federal Republic of Germany.
Phys Med Biol. 1988 Jan;33(1):53-9. doi: 10.1088/0031-9155/33/1/005.
This paper introduces a method for quantification of mean organ perfusion by the impulse response function using the experimental time-activity curves for the organ of interest and its supplying artery. These are approximated by gamma functions and a general expression for the impulse response function is then derived. In any particular case, the impulse response function can be calculated simply by insertion of the numerical parameters. The procedure combines speed with freedom from random measurement errors. As an example of a clinical application, the impulse response function of healthy brain tissue is calculated and some clinically important parameters are tabulated.
本文介绍了一种通过脉冲响应函数对平均器官灌注进行量化的方法，该方法利用感兴趣器官及其供血动脉的实验时间-活性曲线。这些曲线由伽马函数近似表示，然后推导出脉冲响应函数的一般表达式。在任何特定情况下，只需插入数值参数即可简单计算出脉冲响应函数。该程序兼具速度快和无随机测量误差的优点。作为临床应用的一个例子，计算了健康脑组织的脉冲响应函数，并列出了一些临床上重要的参数。
