Szabó Z, Vosberg H, Sondhaus C A, Feinendegen L E
Eur J Nucl Med. 1985;11(6-7):265-74. doi: 10.1007/BF00279082.
Examination of the input-output events in functioning organs by the use of the impulse-response function (IRF) for a radioactive tracer is gaining more and more ground in nuclear medicine. This study summarizes the development of deconvolution analysis, laying special stress on the 'model-free' approach. System linearity and time invariance are discussed, and means of eliminating noise in IRFs originating from the input and organ-time-activity curves are outlined. Typical IRFs are illustrated by flow diagrams, time-domain curves, and their representation by Laplace transforms. The cases of nondiffusible and diffusible tracers as well as parenchymally extracted and transported substances are discussed. Methods for the derivation of models and for the calculation of physiologically important parameters from the IRFs are suggested.
利用放射性示踪剂的脉冲响应函数（IRF）对功能器官的输入-输出事件进行检测，在核医学领域正越来越受到重视。本研究总结了去卷积分析的发展，特别强调了“无模型”方法。讨论了系统线性和时间不变性，并概述了消除源自输入和器官时间-活度曲线的IRF中噪声的方法。通过流程图、时域曲线及其拉普拉斯变换表示来说明典型的IRF。讨论了不可扩散和可扩散示踪剂的情况，以及实质提取和运输物质的情况。提出了从IRF推导模型和计算生理重要参数的方法。
