在喀麦隆的杜阿拉，大量发热的 Duffy 阴性非洲人被检测出感染了间日疟原虫。
Plasmodium vivax Infections Detected in a Large Number of Febrile Duffy-Negative Africans in Dschang, Cameroon.
机构信息
1Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
2Evangelical University of Cameroon, Bandjoun, Cameroon.
出版信息
Am J Trop Med Hyg. 2021 Jan 12;104(3):987-992. doi: 10.4269/ajtmh.20-1255.
The Duffy blood group is a critical receptor for Plasmodium vivax (P. vivax) invasion of red blood cells, and consequently, P. vivax infections were considered rare in sub-Saharan Africa where the prevalence of Duffy-negativity is high. However, recently, P. vivax infections have been found in Duffy-negative Africans throughout the malaria transmission area of sub-Saharan Africa, raising important questions concerning the molecular composition of these P. vivax clones and the red blood cell receptors that facilitate their invasion. Here, we describe an unusually high number of P. vivax infections in febrile Duffy-negative Africans in Dschang, Cameroon (177 of 500 outpatients), as compared with Santchou (two of 400 outpatients) and Kyé-ossi (two of 101 outpatients), in other areas in Cameroon. In the discussion, we speculate on the possible reasons why Dschang might account for the unusually large numbers of P. vivax infections in Duffy-negative individuals living there.
达菲血型是间日疟原虫（Plasmodium vivax，P. vivax）入侵红细胞的关键受体，因此，在达菲阴性率较高的撒哈拉以南非洲，间日疟原虫感染被认为很少见。然而，最近在整个撒哈拉以南非洲疟疾传播地区的达菲阴性非洲人中发现了间日疟原虫感染，这引发了关于这些间日疟原虫克隆的分子组成以及有助于其入侵的红细胞受体的重要问题。在这里，我们描述了在喀麦隆的 Dschang（177 例发热的达菲阴性非洲人中的 500 例门诊患者）中，间日疟原虫感染的发热的达菲阴性非洲人数量异常高，而在 Santchou（400 例门诊患者中的 2 例）和 Kyé-ossi（101 例门诊患者中的 2 例）中，在喀麦隆的其他地区，间日疟原虫感染的数量则相对较少。在讨论中，我们推测了为什么 Dschang 可能导致生活在那里的达菲阴性个体中出现异常大量的间日疟原虫感染的可能原因。
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