Division of Infectious Diseases and Tropical Medicine, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.
Interdisciplinary Center for Infectious Diseases, Leipzig University Medical Center, Leipzig, Germany.
PLoS One. 2021 Feb 3;16(2):e0246312. doi: 10.1371/journal.pone.0246312. eCollection 2021.
Understanding mild to moderate symptoms of coronavirus disease 2019 (Covid-19) is important in order to identify active cases early and thus counteract transmission.
In March 2020, Leipzig University Hospital established an outpatient clinic for patients potentially infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Confirmed cases with mild to moderate symptoms self-isolated at home and were followed-up by daily telephone calls for at least 14 days. Symptoms and course of illness of these patients are reported here.
From March 20 to April 17, 2020, 1460 individuals were tested for SARS-CoV-2 by naso- or oropharyngeal swab for real-time polymerase chain reaction (RT-PCR). Covid-19 was confirmed in 91 (6.2%) patients, of which 87 were included in the final analysis. Patients presented for testing after a mean of 5.9 days (IQR = 2.0-8.5). The median age was 37.0 years (IQR = 28.5-53), and 48 (55.2%) were female. Five (5.7%) patients required hospital admission during the course of illness. Most frequently reported symptoms were fatigue (n = 64, 74%), cough (n = 58, 67%), and hyposmia/hypogeusia (n = 44, 51%). In contrast to previous reports, fever occurred in less than a third of patients (n = 25, 29%). By day 14, more than half of the patients had recovered completely (n = 37/70, 52.9%).
Fever seems to be less common in patients of relatively young age diagnosed with mild to moderate Covid-19. This suggests that body temperature alone may be an insufficient indicator of SARS-CoV-2 infection.
了解 2019 年冠状病毒病（COVID-19）的轻度至中度症状很重要，以便早期发现活动病例，从而阻止传播。
2020 年 3 月，莱比锡大学医院为可能感染严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的患者设立了一个门诊诊所。确诊的轻度至中度症状的病例在家中进行自我隔离，并通过每日电话随访至少 14 天。在此报告这些患者的症状和疾病过程。
2020 年 3 月 20 日至 4 月 17 日，通过鼻咽或口咽拭子实时聚合酶链反应（RT-PCR）对 1460 人进行了 SARS-CoV-2 检测。91 例（6.2%）患者COVID-19 检测结果为阳性，其中 87 例纳入最终分析。患者平均在出现症状后 5.9 天（IQR=2.0-8.5）就诊。中位年龄为 37.0 岁（IQR=28.5-53），48 例（55.2%）为女性。5 例（5.7%）患者在病程中需要住院治疗。最常报告的症状是疲劳（n=64，74%）、咳嗽（n=58，67%）和嗅觉/味觉减退（n=44，51%）。与先前的报告相比，发热患者不到三分之一（n=25，29%）。到第 14 天，超过一半的患者已完全康复（n=37/70，52.9%）。
在确诊为轻度至中度 COVID-19 的相对年轻的患者中，发热似乎不太常见。这表明体温本身可能不是 SARS-CoV-2 感染的充分指标。
