Department of Anatomy and Developmental Biology, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; German Centre for Cardiovascular Research (DZHK), Germany.
Department of Anatomy and Developmental Biology, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; German Centre for Cardiovascular Research (DZHK), Germany.
Curr Opin Cell Biol. 2021 Apr;69:80-87. doi: 10.1016/j.ceb.2020.12.014. Epub 2021 Jan 31.
During development, discrete cell fates are established in precise spatiotemporal order guided by morphogen signals. These signals converge in the nucleus to induce transcriptional and epigenetic programming that determines cell fate. Once cell identity is established, cell programs have to be accurately sustained through multiple rounds of cell division, during which DNA replication serves as a window of opportunity for altering cell fate. In this review, we summarize recent advances in understanding the molecular players that underlie epigenetic memory of cell fate decisions, with a particular focus on histone modifications and mitotic bookmarking factors. We also discuss the different mechanisms of inheritance of repressed and active chromatin states.
在发育过程中，离散的细胞命运是在形态发生信号的精确时空顺序的指导下建立的。这些信号在核内汇聚，诱导决定细胞命运的转录和表观遗传编程。一旦细胞身份确定，细胞程序必须通过多次细胞分裂准确维持，在此期间，DNA 复制为改变细胞命运提供了机会窗口。在这篇综述中，我们总结了近年来对决定细胞命运的表观遗传记忆的分子机制的理解的进展，特别关注组蛋白修饰和有丝分裂书签因子。我们还讨论了抑制和激活染色质状态的不同遗传机制。
