Laboratory for Stem Cell & Retinal Regeneration, The Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Laboratory, Beijing 100730 China.
Stem Cell Res. 2021 Mar;51:102200. doi: 10.1016/j.scr.2021.102200. Epub 2021 Jan 27.
Recently, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has spread around the world and is receiving worldwide attention. Approximately 20% of infected patients are suffering from severe disease of multiple systems and in danger of death, while the ocular complications of SARS-CoV-2-infected patients have not been reported generally. Herein, we focus on two major receptors of SARS-CoV-2, ACE2 and CD147 (BSG), in human ocular cells, and interpret the potential roles of coronaviruses in human ocular tissues and diseases.
最近，由严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）引起的 2019 冠状病毒病（COVID-19）在全球范围内传播，受到全球关注。大约 20%的感染患者患有多系统严重疾病，有死亡危险，而 SARS-CoV-2 感染患者的眼部并发症尚未普遍报道。在此，我们重点关注 SARS-CoV-2 的两个主要受体，即血管紧张素转换酶 2（ACE2）和 CD147（BSG），在人眼细胞中的作用，并解释冠状病毒在人眼组织和疾病中的潜在作用。
