Department of Mental Health and Public Medicine, Section of Infectious Diseases, University of Campania "Luigi Vanvitelli", Largo Madonna delle Grazie n. 1, 80138, Naples, Italy.
Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80131, Naples, Italy.
Infection. 2021 Dec;49(6):1265-1275. doi: 10.1007/s15010-021-01706-6. Epub 2021 Oct 5.
Kidney transplant recipients and patients on the waiting list for kidney transplant who acquire SARS-CoV-2 infection are at serious risk of developing severe COVID-19, with an increased risk of mortality for the their immunosuppressive state; other risk factors for mortality have been identified in some comorbidities such as obesity, diabetes, asthma and chronic lung disease.
The COVID-19 pandemic has led to a sharp reduction in kidney transplants in most countries, mainly due to the concern of patients on the waiting list for their potential increased susceptibility to acquire SARS-CoV-2 infection in healthcare facilities and for the difficulties of transplant centers to ensure full activity as hospitals have had to focus most of their attention on COVID-19 patients. Indeed, while the infection curve continued its exponential rise, there was a vertical decline in kidney donation/transplant activity.
This review article focuses on the damage induced by SARS-CoV-2 infection on kidney and on the adverse effect of this pandemic on the entire kidney transplant sector.
感染 SARS-CoV-2 的肾移植受者和等待肾移植的患者，由于免疫抑制状态，发生严重 COVID-19 的风险很高，死亡率增加；在一些合并症中已经确定了其他死亡风险因素，如肥胖、糖尿病、哮喘和慢性肺病。
COVID-19 大流行导致大多数国家的肾移植数量急剧减少，主要是由于担心等待名单上的患者在医疗机构中可能更容易感染 SARS-CoV-2，以及移植中心难以确保全面开展活动，因为医院不得不将大部分注意力集中在 COVID-19 患者身上。事实上，虽然感染曲线继续呈指数级上升，但肾脏供体/移植活动却垂直下降。
本文综述了 SARS-CoV-2 感染对肾脏造成的损害，以及这一流行病对整个肾移植领域的不利影响。
