Department of Gastroenterology, St. Luke's International Hospital, Tokyo, Japan.
Department of Medicine, St. Luke's International Hospital, Tokyo, Japan.
Dig Dis. 2021;39(6):646-652. doi: 10.1159/000514930. Epub 2021 Feb 3.
Background & Aim: This study aimed to evaluate the association between the frequency of daily toothbrushing and the development of nonalcoholic fatty liver disease (NAFLD).
A retrospective longitudinal study was conducted from 2005 to 2012 at the Center for Preventive Medicine at St. Luke's International Hospital, Japan. Data on all participants who underwent a health checkup during the study period were collected. NAFLD was diagnosed by abdominal ultrasonography, and all participants who were diagnosed with NAFLD at the time of their initial visit, consumed alcohol in any amount, or had received only one health checkup were excluded. The questionnaire for the frequency of daily toothbrushing was conducted as part of health checkups. The primary outcome was the risk of developing NAFLD according to the frequency of daily toothbrushing (1-2 times a day or 3 times a day) compared to those who brush teeth once or less than once a day.
Data were collected from 25,804 people. A total of 3,289 (12.7%) participants developed NAFLD. The mean age was 45.2 years, and 6,901 (26.7%) of the participants were male. The risk of developing NAFLD significantly decreased with increased frequency of daily toothbrushing. Adjusted odds ratios (ORs) are as follows: brushing teeth 1-2 times a day (OR: 0.85, 95% confidence interval [CI]: 0.77-0.95) and 3 times a day (OR: 0.74, 95% CI: 0.67-0.82).
Frequent toothbrushing was shown to significantly reduce the risk of developing NAFLD.
本研究旨在评估每日刷牙频率与非酒精性脂肪性肝病（NAFLD）发展之间的关联。
本研究是一项于 2005 年至 2012 年在日本圣卢克国际医院预防医学中心进行的回顾性纵向研究。收集了所有在研究期间接受健康检查的参与者的数据。NAFLD 通过腹部超声诊断，所有在初次就诊时被诊断为 NAFLD、饮酒或仅接受一次健康检查的参与者均被排除在外。每日刷牙频率的问卷调查作为健康检查的一部分进行。主要结局是根据每日刷牙频率（1-2 次/天或 3 次/天）与每日刷牙 1 次或更少次的参与者相比，发展为 NAFLD 的风险。
共收集了 25804 人的数据。共有 3289 名（12.7%）参与者发展为 NAFLD。平均年龄为 45.2 岁，6901 名（26.7%）参与者为男性。随着每日刷牙频率的增加，发展为 NAFLD 的风险显著降低。调整后的优势比（OR）如下：每天刷牙 1-2 次（OR：0.85，95%置信区间 [CI]：0.77-0.95）和每天刷牙 3 次（OR：0.74，95% CI：0.67-0.82）。
频繁刷牙可显著降低发展为 NAFLD 的风险。
