Division of Oral & Maxillofacial Surgery, Department of Dentistry, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, North Carolina, United States of America.
PLoS One. 2021 May 27;16(5):e0243686. doi: 10.1371/journal.pone.0243686. eCollection 2021.
Non-alcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome. Periodontitis, as chronic inflammatory destructive disease, is associated metabolic syndromes bidirectionally. Toothbrushing is an essential and important way to manage periodontitis through mechanical removal of biofilm at periodontal tissue. We aimed to assess the association between toothbrushing frequency and the prevalent NAFLD in nationally representative Korean adults. Among adults aged 19 years and older who participated in the Korea National Health and Nutrition Examination Survey in 2010, a total of 6,352 subjects were analyzed. NAFLD was defined as fatty liver index ≥60. Multiple logistic regression analysis was used to estimate multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs). An inverse association between toothbrushing frequency and NAFLD was found. The adjusted ORs (95% CIs) of NALFD was 0.56 (0.35-0.91) in the group who performed toothbrushing ≥ 3 per day compared to the group that performed toothbrushing ≤ 1 per day. For those with toothbrushing frequency ≤1 per day, the adjusted OR (95% CIs) of NAFLD was 2.26 (1.22-4.19) in smokers and 4.52 (1.97-10.38) in subjects with diabetes mellitus (DM), compared to those without the disease and with toothbrushing frequency ≥2 per day, respectively. Our results indicate that higher frequency of toothbrushing is inversely associated with NAFLD. As a modifiable oral habit, regular toothbrushing may be recommended to lower risk of NAFLD, especially in high risk groups such as smokers and diabetic patients.
非酒精性脂肪性肝病（NAFLD）被认为是代谢综合征的肝脏表现。牙周炎作为一种慢性炎症破坏性疾病，与代谢综合征双向相关。刷牙是通过机械清除牙周组织中的生物膜来管理牙周炎的重要方法。我们旨在评估刷牙频率与韩国成年人普遍存在的非酒精性脂肪性肝病之间的关联。在 2010 年参加韩国国家健康和营养检查调查的 19 岁及以上成年人中，共分析了 6352 名受试者。NAFLD 的定义为脂肪肝指数≥60。使用多变量逻辑回归分析来估计多变量调整后的优势比（OR）和 95％置信区间（CI）。发现刷牙频率与 NAFLD 呈负相关。与每天刷牙≤1 次的组相比，每天刷牙≥3 次的组发生 NAFLD 的调整 OR（95％CI）为 0.56（0.35-0.91）。对于每天刷牙≤1 次的人群，与不患有该疾病且每天刷牙≥2 次的人群相比，吸烟者发生 NAFLD 的调整 OR（95％CI）为 2.26（1.22-4.19），糖尿病患者（DM）的调整 OR（95％CI）为 4.52（1.97-10.38）。我们的结果表明，刷牙频率越高，NAFLD 的风险越低。作为一种可改变的口腔习惯，定期刷牙可能有助于降低 NAFLD 的风险，尤其是在吸烟者和糖尿病患者等高危人群中。
