Xu W J, Ye Q
Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, Beijing Chaoyang Hospitial, Capital Medical University, Beijing 100020, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2021 Jan 20;39(1):69-73. doi: 10.3760/cma.j.cn121094-20200227-00088.
Silicosis is caused by long-term exposure to dust containing crystalline silica. However, silica exposure, which may lead to autoimmune dysfunction, is associated with autoimmune diseases such as rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus, idiopathic inflammatory myopathy and anti-central granulocyte cytoplasmic antibody associated vasculitis. With silica exposure autoimmune diseases may exist with or without silicosis. This article reviews recent research on silica-associated autoimmune diseases such as the concept, epidemiology, clinical characteristics and potential mechanisms to improve the understanding of the disease and promote the formulation of diagnostic criteria and treatment plans.
矽肺是长期接触含结晶二氧化硅的粉尘所致。然而，可能导致自身免疫功能障碍的二氧化硅暴露与类风湿关节炎、系统性硬化症、系统性红斑狼疮、特发性炎性肌病及抗中性粒细胞胞浆抗体相关性血管炎等自身免疫性疾病有关。接触二氧化硅后，自身免疫性疾病可能伴或不伴有矽肺而存在。本文综述了近期关于二氧化硅相关自身免疫性疾病的研究，如概念、流行病学、临床特征及潜在机制，以增进对该疾病的认识并促进诊断标准和治疗方案的制定。
