探究银屑病患者治疗选择的决定因素：一项在美国和德国开展的离散选择实验研究。
Exploring determinants of psoriasis patients' treatment choices: a discrete-choice experiment study in the United States and Germany.
机构信息
Departmemt of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
RTI Health Solutions, Research Triangle Park, NC, USA.
出版信息
J Dermatolog Treat. 2022 May;33(3):1511-1520. doi: 10.1080/09546634.2020.1839007. Epub 2021 Feb 3.
BACKGROUND
Biologic psoriasis treatments are differentiated by efficacy, side effects, and other attributes.
OBJECTIVE
Determine attributes of biologic psoriasis treatments that drive patients' treatment choices.
METHODS
Respondents (USA: = 300; Germany: = 300) with moderate-to-severe psoriasis completed a discrete-choice-experiment survey, choosing between hypothetical treatments characterized by attributes with varying levels: chance of clear skin after 1 year, number of first-year treatments, first-year risks of mild-to-moderate injection site reaction (ISR) and serious infection, and years of proven efficacy/safety.
RESULTS
U.S. respondents most valued clear skin (conditional relative importance, 1.88; < .05). While other attributes were of generally equivalent importance, ISR risk outweighed serious-infection risk (1.06 vs. 0.70; < .05). German respondents placed greatest importance on ISR risk (1.61; < .05) and clear skin (1.49; < .05).
LIMITATIONS
Respondents evaluated hypothetical treatments and were recruited from web panels.
CONCLUSIONS
Clear skin and ISR risk are stronger drivers of treatment choice than injection frequency and infection risk.
背景
生物制剂治疗银屑病的疗效、副作用和其他属性存在差异。
目的
确定影响患者治疗选择的生物制剂银屑病治疗属性。
方法
300 名美国和 300 名德国中重度银屑病患者完成了一项离散选择实验调查，在不同属性水平的假设治疗方案之间进行选择：1 年后达到皮肤完全清除的几率、第一年的治疗次数、第一年轻度至中度注射部位反应（ISR）和严重感染的风险，以及已证实的疗效/安全性年限。
结果
美国患者最看重皮肤完全清除（条件相对重要性，1.88；<.05）。虽然其他属性的重要性大致相当，但 ISR 风险超过严重感染风险（1.06 比 0.70；<.05）。德国患者最看重 ISR 风险（1.61；<.05）和皮肤完全清除（1.49；<.05）。
局限性
受访者评估了假设的治疗方案，并且是从网络面板中招募的。
结论
皮肤完全清除和 ISR 风险是比注射频率和感染风险更强的治疗选择驱动因素。
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