Department of Emergency, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, No. 7 Weiwu Road, Zhengzhou, 450003, Henan, China.
College of Food Science and Technology, Henan University of Technology, Zhengzhou, 450001, China.
BMC Cardiovasc Disord. 2021 Feb 3;21(1):69. doi: 10.1186/s12872-020-01835-0.
This meta-analysis based on prospective cohort studies aimed to evaluate the associations of lipid profiles with the risk of major adverse cardiovascular outcomes in patients with coronary heart disease (CHD).
The PubMed, Embase, and Cochrane Library electronic databases were systematically searched for prospective cohort study published through December 2019, and the pooled results were calculated using the random-effects model.
Twenty-one studies with a total of 76,221 patients with CHD met the inclusion criteria. The per standard deviation (SD) increase in triglyceride was associated with a reduced risk of major adverse cardiovascular events (MACE). Furthermore, the per SD increase in high-density lipoprotein cholesterol (HDL-C) was associated with a reduced risk of cardiac death, whereas patients with lower HDL-C were associated with an increased risk of MACE, all-cause mortality, and cardiac death. Finally, the risk of MACE was significantly increased in patients with CHD with high lipoprotein(a) levels.
The results of this study suggested that lipid profile variables could predict major cardiovascular outcomes and all-cause mortality in patients with CHD.
本荟萃分析基于前瞻性队列研究，旨在评估血脂谱与冠心病（CHD）患者主要不良心血管结局风险之间的关联。
系统检索了 PubMed、Embase 和 Cochrane Library 电子数据库中截至 2019 年 12 月发表的前瞻性队列研究，并使用随机效应模型计算汇总结果。
21 项研究共纳入 76221 例 CHD 患者，符合纳入标准。甘油三酯每标准差（SD）增加与主要不良心血管事件（MACE）风险降低相关。此外，高密度脂蛋白胆固醇（HDL-C）每 SD 增加与心脏死亡风险降低相关，而 HDL-C 水平较低的患者与 MACE、全因死亡率和心脏死亡风险增加相关。最后，脂蛋白（a）水平较高的 CHD 患者发生 MACE 的风险显著增加。
本研究结果表明，血脂谱变量可预测 CHD 患者的主要心血管结局和全因死亡率。
