MOE-LCSM, School of Mathematics and Statistics, Hunan Normal University, Changsha, Hunan Province, 410081, China.
Key Laboratory of Molecular Epidemiology, Medical College of Hunan Normal University, Changsha, Hunan Province, 410013, China.
Nutr Metab Cardiovasc Dis. 2020 Nov 27;30(12):2159-2170. doi: 10.1016/j.numecd.2020.08.017. Epub 2020 Aug 21.
Dyslipidemia is a common metabolic disease worldwide and also an important predisposing factor for cardiovascular diseases (CVDs). Coffee is loved by people all over the world; however, the association between coffee consumption and blood lipids has yielded inconsistent results. So we carried this meta-analysis to explore the effects of coffee consumption on blood lipids.
Medline, PubMed, Web of science, Embase, and Cochrane Library databases were systematically searched until April 2020. Combined weighted mean differences (WMD) with their 95% confidence interval (CI) were calculated using random-effects models, and between-study heterogeneity was assessed by Cochran's Q test and I statistics. Subgroup analysis and meta-regression analysis were also conducted to explore the potential heterogeneity. A total of 12 RCT studies involving the association between coffee consumption and blood lipid levels were included in the meta-analysis. The pooled results showed that coffee consumption significantly increased total cholesterol (TC) (WMD: 0.21 mmol/L, 95% CI: 0.04; 0.39, P = 0.017), triglyceride (TG) (WMD: 0.12 mmol/L, 95% CI: 0.03; 0.20, P = 0.006) and low-density lipoprotein (LDL-C) (WMD: 0.14 mmol/L, 95% CI: 0.05; 0.24, P = 0.003) while had no significant effect on high-density lipoprotein (HDL-C) (WMD: -0.01 mmol/L, 95% CI: -0.06; 0.04, P = 0.707). Dose-response analysis results revealed significant positive nonlinear associations between coffee consumption and the increase in TC, LDL-C, and TG levels.
Evidence from this meta-analysis suggested that coffee consumption may be associated with an elevated risk for dyslipidemia and CVDs. So a reasonable habit of coffee consumption (<3 cups/d) is essential for the prevention of dyslipidemia.
血脂异常是一种常见的全球性代谢性疾病，也是心血管疾病（CVDs）的重要致病因素。咖啡深受世界各地人们的喜爱；然而，喝咖啡与血脂之间的关系得出的结果并不一致。因此，我们进行了这项荟萃分析，以探讨喝咖啡对血脂的影响。
系统检索了 Medline、PubMed、Web of science、Embase 和 Cochrane Library 数据库，截至 2020 年 4 月。使用随机效应模型计算合并加权均数差（WMD）及其 95%置信区间（CI），并通过 Cochran's Q 检验和 I 统计量评估研究间异质性。还进行了亚组分析和 meta 回归分析以探讨潜在的异质性。共有 12 项 RCT 研究纳入了喝咖啡与血脂水平之间的关联的荟萃分析。汇总结果显示，喝咖啡可显著升高总胆固醇（TC）（WMD：0.21mmol/L，95%CI：0.04；0.39，P=0.017）、三酰甘油（TG）（WMD：0.12mmol/L，95%CI：0.03；0.20，P=0.006）和低密度脂蛋白胆固醇（LDL-C）（WMD：0.14mmol/L，95%CI：0.05；0.24，P=0.003），而对高密度脂蛋白胆固醇（HDL-C）（WMD：-0.01mmol/L，95%CI：-0.06；0.04，P=0.707）没有显著影响。剂量反应分析结果表明，咖啡摄入量与 TC、LDL-C 和 TG 水平升高之间存在显著的正非线性关联。
本荟萃分析的证据表明，喝咖啡可能与血脂异常和 CVDs 的风险增加有关。因此，养成合理的喝咖啡习惯（<3 杯/天）对于预防血脂异常是必要的。
