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Glucose-6-phosphate dehydrogenase neutralizes stresses by supporting reductive glutamine metabolism and AMPK activation.

作者信息

Zhong Benfu, Jiang Dewei, Hong Yang, Li Lifang, Qiu Li, Yang Ronghui, Jin Xiaohan, Song Yawen, Chen Ceshi, Li Binghui

机构信息

Department of Cancer Cell Biology and National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, P. R. China.

Department of Biochemistry and Molecular Biology, Capital Medical University, Beijing, 100069, P.R. China.

出版信息

Signal Transduct Target Ther. 2021 Feb 4;6(1):46. doi: 10.1038/s41392-020-00399-x.

DOI:10.1038/s41392-020-00399-x
PMID:33536406
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7859178/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9121/7859178/1560814d785a/41392_2020_399_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9121/7859178/1560814d785a/41392_2020_399_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9121/7859178/1560814d785a/41392_2020_399_Fig1_HTML.jpg

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Inhibiting both proline biosynthesis and lipogenesis synergistically suppresses tumor growth.同时抑制脯氨酸生物合成和脂肪生成可协同抑制肿瘤生长。
J Exp Med. 2020 Mar 2;217(3). doi: 10.1084/jem.20191226.
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A genetically encoded tool for manipulation of NADP/NADPH in living cells.一种用于在活细胞中操纵NADP/NADPH的基因编码工具。
Nat Chem Biol. 2017 Oct;13(10):1088-1095. doi: 10.1038/nchembio.2454. Epub 2017 Aug 7.
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Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio.通过调控NAD⁺/NADH比值对线粒体电子传递链进行互补作用。
泛癌分析表明，G6PD是多种癌症的预后生物标志物和治疗靶点。
Front Oncol. 2023 Aug 3;13:1183474. doi: 10.3389/fonc.2023.1183474. eCollection 2023.
4
G6PD promotes cell proliferation and dexamethasone resistance in multiple myeloma via increasing anti-oxidant production and activating Wnt/β-catenin pathway.葡萄糖-6-磷酸脱氢酶通过增加抗氧化剂生成和激活Wnt/β-连环蛋白通路，促进多发性骨髓瘤细胞增殖并导致地塞米松耐药。
Exp Hematol Oncol. 2022 Oct 21;11(1):77. doi: 10.1186/s40164-022-00326-6.
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Proteomic and metabolomic profiling of acupuncture for migraine reveals a correlative link via energy metabolism.偏头痛针灸治疗的蛋白质组学和代谢组学分析揭示了通过能量代谢的相关联系。
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