Kim Eun-Mi, Jeong Hwan-Jeong
Department of Nuclear Medicine, Molecular Imaging & Therapeutic Medicine Research Center, Research Institute of Clinical Medicine of Jeonbuk National University and Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea.
Chonnam Med J. 2021 Jan;57(1):27-35. doi: 10.4068/cmj.2021.57.1.27. Epub 2021 Jan 25.
Liposomes, with their flexible physicochemical and biophysical properties, continue to be studied as an important potential a critical drug delivery system. Liposomes have overcome the challenges of conventional free drug therapy by encapsulating therapeutic agents, thereby improving biodistribution and reducing systemic toxicity. New imaging modalities and interpretation techniques, as well as new techniques for targetable system formulation technique, and tumor environmental information, have affected the search for a means of overcoming the difficulties of conventional liposome formulation. In this review, we briefly discuss how liposomal formulation has been applied across the biomedical field, particularly as a therapy, and the role it may play in the future, when paired with new developments in diagnosis and theranostics. The biological challenges that still remain and the translational obstacles are discussed.
脂质体具有灵活的物理化学和生物物理性质，作为一种重要的潜在关键药物递送系统，仍在持续研究中。脂质体通过包裹治疗剂克服了传统游离药物疗法的挑战，从而改善了生物分布并降低了全身毒性。新的成像模式和解读技术，以及靶向系统制剂技术和肿瘤环境信息的新技术，影响了克服传统脂质体制剂困难方法的探索。在本综述中，我们简要讨论了脂质体制剂如何在生物医学领域得到应用，特别是作为一种治疗方法，以及当与诊断和治疗诊断学的新进展相结合时，它在未来可能发挥的作用。还讨论了仍然存在的生物学挑战和转化障碍。
