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HDL-C and Cardiovascular Risk: You Don't Need to Worry about Extremely High HDL-C Levels.高密度脂蛋白胆固醇与心血管风险：无需担忧高密度脂蛋白胆固醇水平极高的情况。
J Lipid Atheroscler. 2021 Jan;10(1):57-61. doi: 10.12997/jla.2021.10.1.57. Epub 2021 Jan 18.
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Ask the Doctor: I am a woman, age 48, in generally good health, although I've gained about 10 pounds over the past two years. My LDL cholesterol us 142 mg/dL and my HDL cholesterol is 58 mg/dL. I looked at the news reports on the new cholesterol guidelines and was extremely unhappy to see that my LDL is "borderline high". My doctor says I don't need drug therapy. What do you think?向医生提问：我是一名48岁的女性，总体健康状况良好，不过在过去两年里体重增加了约10磅。我的低密度脂蛋白胆固醇为142毫克/分升，高密度脂蛋白胆固醇为58毫克/分升。我看了关于新胆固醇指南的新闻报道，看到我的低密度脂蛋白处于“临界高值”，心里非常不高兴。我的医生说我不需要药物治疗。你怎么看？
Harv Heart Lett. 2001 Sep;12(1):8.
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What you don't see can hurt you.你看不见的东西可能会伤害你。
N Y State Dent J. 1993 Mar;59(3):45-7.
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If you don't need change, maybe you don't need sex.如果你不需要改变，也许你就不需要性。
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High-density lipoprotein particles are associated with the risk of mortality from all-causes and cardiovascular diseases (CVDs) in patients with CVD: a systematic review and meta-analysis study.高密度脂蛋白颗粒与心血管疾病（CVD）患者的全因死亡率和心血管疾病（CVD）风险相关：一项系统评价和荟萃分析研究。
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3-Indolepropionic acid mitigates sub-acute toxicity in the cardiomyocytes of epirubicin-treated female rats.3-吲哚丙酸可减轻表柔比星处理雌性大鼠心肌细胞的亚急性毒性。
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本文引用的文献

1
High-Density Lipoprotein Cholesterol and the Risk of Myocardial Infarction, Stroke, and Cause-Specific Mortality: a Nationwide Cohort Study in Korea.高密度脂蛋白胆固醇与心肌梗死、中风及特定病因死亡率的风险：韩国一项全国性队列研究
J Lipid Atheroscler. 2021 Jan;10(1):74-87. doi: 10.12997/jla.2021.10.1.74. Epub 2020 Dec 3.
2
Metabolic health is a determining factor for incident colorectal cancer in the obese population: A nationwide population-based cohort study.代谢健康是肥胖人群中结直肠癌发病的决定因素：一项全国基于人群的队列研究。
Cancer Med. 2021 Jan;10(1):220-229. doi: 10.1002/cam4.3607. Epub 2020 Nov 20.
3
Impact of Transition in Metabolic Health and Obesity on the Incident Chronic Kidney Disease: A Nationwide Cohort Study.代谢健康和肥胖过渡期对慢性肾脏病发病的影响：一项全国性队列研究。
J Clin Endocrinol Metab. 2020 Mar 1;105(3). doi: 10.1210/clinem/dgaa033.
4
Implications of the dynamic nature of metabolic health status and obesity on risk of incident cardiovascular events and mortality: a nationwide population-based cohort study.代谢健康状况和肥胖的动态性质对心血管事件和死亡发生风险的影响：一项全国性基于人群的队列研究。
Metabolism. 2019 Aug;97:50-56. doi: 10.1016/j.metabol.2019.05.002. Epub 2019 May 7.
5
Safety and efficacy of statin therapy.他汀类药物治疗的安全性和有效性。
Nat Rev Cardiol. 2018 Dec;15(12):757-769. doi: 10.1038/s41569-018-0098-5.
6
Examining the paradox of high high-density lipoprotein and elevated cardiovascular risk.探讨高密度脂蛋白水平高与心血管风险升高这一矛盾现象。
J Thorac Dis. 2018 Jan;10(1):109-112. doi: 10.21037/jtd.2017.12.97.
7
Association of CETP Gene Variants With Risk for Vascular and Nonvascular Diseases Among Chinese Adults.载脂蛋白 E 基因多态性与中国成年人血管和非血管疾病风险的关联。
JAMA Cardiol. 2018 Jan 1;3(1):34-43. doi: 10.1001/jamacardio.2017.4177.
8
Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease.胆固醇酯转运蛋白基因的蛋白质截短变异与冠心病风险
Circ Res. 2017 Jun 23;121(1):81-88. doi: 10.1161/CIRCRESAHA.117.311145. Epub 2017 May 15.
9
Extreme high high-density lipoprotein cholesterol is paradoxically associated with high mortality in men and women: two prospective cohort studies.极高的高密度脂蛋白胆固醇水平与男性和女性的高死亡率呈矛盾关系：两项前瞻性队列研究。
Eur Heart J. 2017 Aug 21;38(32):2478-2486. doi: 10.1093/eurheartj/ehx163.
10
Will Big Data Shine Light at the End of the Tunnel for HDL?大数据能否为高密度脂蛋白（HDL）带来曙光？
J Am Coll Cardiol. 2016 Nov 8;68(19):2084-2085. doi: 10.1016/j.jacc.2016.08.039.

HDL-C and Cardiovascular Risk: You Don't Need to Worry about Extremely High HDL-C Levels.

作者信息

Cho Yun Kyung, Jung Chang Hee

机构信息

Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.

Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

出版信息

J Lipid Atheroscler. 2021 Jan;10(1):57-61. doi: 10.12997/jla.2021.10.1.57. Epub 2021 Jan 18.

DOI:10.12997/jla.2021.10.1.57
PMID:33537253
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7838515/
Abstract
摘要