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阿拉伯联合酋长国艾因市儿童和青少年的新冠病毒病——一项回顾性横断面研究

Covid-19 in Children and Young Adolescents in Al Ain, United Arab Emirates- a Retrospective Cross-Sectional Study.

作者信息

Elghoudi Ahmed, Aldhanhani Huda, Ghatasheh Ghassan, Sharif Elsadeq, Narchi Hassib

机构信息

Department of Pediatrics, Al Ain Hospital, Al Ain, United Arab Emirates.

The Department of Paediatrics, College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates.

出版信息

Front Pediatr. 2021 Jan 18;8:603741. doi: 10.3389/fped.2020.603741. eCollection 2020.

Abstract

In this retrospective single-center study, we report our experience with a cohort of children admitted to our hospital in Al Ain City, United Arab Emirates, with confirmed COVID-19. We also compare our findings to similar reports in the literature. Between 1st March and 31st May 2020, we reviewed the electronic patient medical records of all children with confirmed COVID-19 (ICD-10 code U07.1) managed in Al Ain hospital, designated as the only COVID-19 center in the city. There were 288 children admitted with a confirmed diagnosis of Covid-19 during the study period (mean age 7.3 years, median 6.5, range 1 month to 16.9 years). The age-specific point prevalence was the highest under the age of 5 years (mean 2.0 per 1,000, 95% ci 1.7, 2.4) and decreased progressively to 0.6 per 1,000 (95% ci 0.4, 0.9) over the age of 14 years. Hospital admission was required for 193 (67%) children while 95 (33%) were discharged from the emergency department. Most children ( = 214, 74%) had been exposed to a family member with suspected or confirmed COVID-19 and asthma which was the most frequent comorbidity ( = 37, 13%). The most common symptoms were cough ( = 130, 45%), fever ( = 14, 4.8%), upper respiratory tract infection ( = 93, 32.3%), and lower respiratory tract infection in 28 (9.7%). None of the children presented with acute respiratory distress syndrome, neurological symptoms, sepsis, or septic shock. Neutropenia (absolute neutrophil count or ANC< 1.5 × 10/L) was observed in 10.4% and thrombocytopenia (<150 platelets × 10/L) in 72% of children. Nineteen patients (9%) had abnormal imaging studies (chest X-ray and chest computed tomography). Abnormalities were bilateral in six (43%), right-sided in seven (50%) with only one child (7%) with left-sided involvement. None of the children required invasive respiratory support, but four (1.4%) required noninvasive respiratory support. The median length of hospital stay was 3.3 days [1.9, 5.9]. There were no deaths in the hospital even in those with comorbidities. Our results confirm previous reports of mild illness of COVID-19 in our child population, even in those with comorbidities. The age-standardized prevalence was higher in children (<5 years) compared to young adolescents.

摘要

在这项回顾性单中心研究中,我们报告了在阿拉伯联合酋长国艾因市我们医院收治的确诊为新冠病毒病(COVID-19)儿童队列的情况。我们还将我们的研究结果与文献中的类似报告进行了比较。2020年3月1日至5月31日期间,我们查阅了在艾因医院接受治疗的所有确诊为COVID-19(国际疾病分类第十版编码U07.1)儿童的电子病历,该医院被指定为该市唯一的COVID-19中心。在研究期间,有288名儿童确诊为COVID-19入院(平均年龄7.3岁,中位数6.5岁,范围1个月至16.9岁)。5岁以下儿童的年龄特异性点患病率最高(平均每1000人中有2.0例,95%置信区间为1.7至2.4),14岁以上则逐渐降至每1000人中有0.6例(95%置信区间为0.4至0.9)。193名(67%)儿童需要住院治疗,而95名(33%)从急诊科出院。大多数儿童(n = 214,74%)曾接触过疑似或确诊为COVID-19的家庭成员,哮喘是最常见的合并症(n = 37,13%)。最常见的症状是咳嗽(n = 130,45%)、发热(n = 14,4.8%)、上呼吸道感染(n = 93,32.3%),28名(9.7%)有下呼吸道感染。没有儿童出现急性呼吸窘迫综合征、神经系统症状、败血症或感染性休克。10.4%的儿童观察到中性粒细胞减少(绝对中性粒细胞计数或ANC<1.5×10⁹/L),72%的儿童有血小板减少(<150×10⁹/L血小板)。19名患者(9%)影像学检查(胸部X线和胸部计算机断层扫描)异常。6例(43%)异常为双侧性,7例(50%)为右侧,只有1例儿童(7%)为左侧受累。没有儿童需要有创呼吸支持,但4例(1.4%)需要无创呼吸支持。住院中位时间为3.3天[1.9,5.9]。即使是有合并症的患者,医院内也无死亡病例。我们的结果证实了先前关于我们儿童群体中COVID-19病情较轻的报告,即使是有合并症的儿童也是如此。与青少年相比,<5岁儿童的年龄标准化患病率更高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae31/7848192/48bc33c78133/fped-08-603741-g0001.jpg

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