Department of Translational Research, Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Am Schwarzenberg 15, 97078 Würzburg, Germany.
Institute of Experimental Biomedicine, University Hospital Würzburg, Josef-Schneider-Straße 2, 97080 Würzburg, Germany.
Cardiovasc Res. 2022 Jan 7;118(1):37-52. doi: 10.1093/cvr/cvab036.
The interplay between the cardiovascular system, metabolism, and inflammation plays a central role in the pathophysiology of a wide spectrum of cardiovascular diseases, including heart failure. Here, we provide an overview of the fundamental aspects of the interrelation between inflammation and metabolism, ranging from the role of metabolism in immune cell function to the processes how inflammation modulates systemic and cardiac metabolism. Furthermore, we discuss how disruption of this immuno-metabolic interface is involved in the development and progression of cardiovascular disease, with a special focus on heart failure. Finally, we present new technologies and therapeutic approaches that have recently emerged and hold promise for the future of cardiovascular medicine.
心血管系统、代谢和炎症之间的相互作用在广泛的心血管疾病的病理生理学中起着核心作用，包括心力衰竭。在这里，我们提供了炎症和代谢之间相互关系的基本方面的概述，从代谢在免疫细胞功能中的作用到炎症如何调节全身和心脏代谢的过程。此外，我们还讨论了这种免疫代谢界面的破坏如何参与心血管疾病的发展和进展，特别关注心力衰竭。最后，我们介绍了最近出现的新技术和治疗方法，它们为心血管医学的未来带来了希望。
