Mohamed Marwa, Shehata Hanan Abdel Aaty, Fahmy Nahed Fathallah, Saleh Ramadan
Department of Dermatology, Venereology and Andrology, Tahta General Hospital, Ministry of Health and Population, Sohag, Egypt.
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt.
J Cosmet Dermatol. 2022 Dec;21(12):7100-7106. doi: 10.1111/jocd.15399. Epub 2022 Sep 25.
One of the most prevalent skin disorders is acne vulgaris. It is a distressing problem among young adults and adolescents. The pathophysiology of AV is significantly influenced by certain immune response cells. Acne's localized tissue inflammatory reactions are brought on by the bacteria Cutibacterium acnes, which also causes the release of several inflammatory mediators.
To measure the serum levels of IL-1 and IL-12, two pro-inflammatory cytokines, and IL-10, an anti-inflammatory cytokine, in AV patients and link those levels with the severity of the condition.
This study included 19 males and 23 females with AV(n = 42), with mean age of 21.79 ± 3.5. The control group included 19 males and 23 female (n = 42) with mean age of 22.05 ± 3.3 (p = 0.729). Serum levels of IL-1β was significantly higher in patients with AV as than controls (p < 0.001). Similarly, the serum levels of IL-12 were significantly higher in AV cases than controls (p < 0.001). On the contrary, the median IL-10 was significantly lower in AV cases than controls (p = 0.015). The correlation between serum levels of IL-1β and IL-12 in AV patients and disease severity was insignificant (r = -0.04, p = 0.404) and (r = -0.19, p = 0.118, respectively). (r = -0.19, p = 0.118) On the contrary, there was a significant negative correlation between serum levels of IL-10 in AV patients and disease severity (r = -0.43, p = 0.003).
Our results indicate significant alterations in the monocyte-derived cytokine (MDCs) profile in patients with AV, IL-1 and IL-12 serum levels rose while IL-10 levels fell, reflecting an increase in pro-inflammatory cytokines and a decrease in anti-inflammatory cytokines. These highlight the important role played by monocytes in the pathogenesis of AV.
寻常痤疮是最常见的皮肤疾病之一。它是年轻成年人和青少年中令人苦恼的问题。寻常痤疮的病理生理学受到某些免疫反应细胞的显著影响。痤疮丙酸杆菌引发痤疮的局部组织炎症反应，该细菌还会导致多种炎症介质的释放。
测量寻常痤疮患者血清中两种促炎细胞因子白细胞介素-1（IL-1）和白细胞介素-12（IL-12）以及一种抗炎细胞因子白细胞介素-10（IL-10）的水平，并将这些水平与病情严重程度联系起来。
本研究纳入了42例寻常痤疮患者，其中男性19例，女性23例，平均年龄为21.79±3.5岁。对照组包括42例（男性19例，女性23例）平均年龄为22.05±3.3岁的个体（p = 0.729）。寻常痤疮患者血清IL-1β水平显著高于对照组（p < 0.001）。同样，寻常痤疮患者血清IL-12水平也显著高于对照组（p < 0.001）。相反，寻常痤疮患者血清IL-10中位数显著低于对照组（p = 0.015）。寻常痤疮患者血清IL-1β和IL-12水平与疾病严重程度之间的相关性不显著（r = -0.04，p = 0.404）以及（r = -0.19，p = 0.118）。（r = -0.19，p = 0.118）相反，寻常痤疮患者血清IL-10水平与疾病严重程度之间存在显著负相关（r = -0.43，p = 0.003）。
我们的结果表明寻常痤疮患者单核细胞衍生细胞因子（MDCs）谱有显著改变，IL-1和IL-12血清水平升高而IL-10水平降低，反映出促炎细胞因子增加和抗炎细胞因子减少。这些突出了单核细胞在寻常痤疮发病机制中所起的重要作用。
