Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, Florida.
Pulmonary Division, Department of Pediatrics, University of Florida, Gainesville, Florida.
J Clin Sleep Med. 2021 May 1;17(5):1121-1123. doi: 10.5664/jcsm.9112.
During upward titration of a dose of sodium oxybate therapy for narcolepsy with cataplexy, a 25-year-old woman was observed by her husband to have new onset of knuckle-cracking and moaning behaviors during sleep ≥1 nights each week. The patient did previously occasionally crack her knuckles during the day (but never at night). These behaviors had not been evaluated by polysomnography. After transition of care, polysomnography with video monitoring was ordered and revealed 2 knuckle-cracking episodes that developed out of stage N2 sleep and were likely a non-rapid eye movement sleep parasomnia associated with sodium oxybate treatment.
在治疗伴有猝倒症的发作性睡病时，对钠缬草氨酸剂量进行上调期间，一位 25 岁的女性被其丈夫观察到，每周至少有 1 晚在睡眠期间出现新的指关节噼啪作响和呻吟行为。该患者此前偶尔会在白天（但从未在晚上）掰手指关节。这些行为尚未通过多导睡眠图进行评估。在过渡治疗后，安排了视频监测的多导睡眠图，结果显示有 2 次指关节噼啪作响的发作，这些发作发生在 N2 睡眠阶段，可能与钠缬草氨酸治疗有关的非快速眼动睡眠行为障碍。
