Wedzicha J A, Cotter F E, Empey D W
Department of Thoracic Medicine, London Hospital, Whitechapel.
Thorax. 1988 Jan;43(1):61-4. doi: 10.1136/thx.43.1.61.
Platelet size, expressed as mean platelet volume, was estimated in 35 patients with chronic airflow obstruction and a wide range of arterial oxygen tension (PaO2) values. In these patients there was a negative correlation between MPV and PaO2 (r = -0.70). Mean platelet volume was greater (9.41 (0.86) fl) in 20 patients with an arterial PaO2 of 8 kPa (60 mm Hg) or less than in 18 normal subjects (8.21 (0.63) fl; p less than 0.001). After 24 hours of supplemental oxygen treatment there was a small fall in mean platelet volume, from 9.47 (1.06) to 8.96 (0.8) fl (p less than 0.05) in 12 hypoxaemic patients (PaO2 breathing air less than or equal to 8 kPa) but no change in nine non-hypoxaemic patients. Larger platelets are considered to be haemostatically more active, leading to abnormal platelet function, which may contribute to the development of pulmonary vascular damage in chronic hypoxaemia. Supplemental oxygen may partially reverse these changes by modifying platelet size and activity.
对35例慢性气流阻塞且动脉血氧分压（PaO2）值范围广泛的患者，测定了以平均血小板体积表示的血小板大小。在这些患者中，平均血小板体积（MPV）与PaO2呈负相关（r = -0.70）。20例动脉PaO2为8kPa（60mmHg）或更低的患者，其平均血小板体积（9.41（0.86）fl）大于18例正常受试者（8.21（0.63）fl；p<0.001）。12例低氧血症患者（呼吸空气时PaO2小于或等于8kPa）经24小时补充氧气治疗后，平均血小板体积略有下降，从9.47（1.06）fl降至8.96（0.8）fl（p<0.05），而9例非低氧血症患者则无变化。较大的血小板被认为在止血方面更活跃，会导致血小板功能异常，这可能促使慢性低氧血症时肺血管损伤的发生。补充氧气可能通过改变血小板大小和活性来部分逆转这些变化。
