Laboratory of Pharmaceutical Technology, Dept. of Pharmacy, School of Health Sciences, University of Patras, 26504 Rio Patras, Greece; Institute of Chemical Engineering Sciences, Foundation for Research and Technology Hellas (FORTH/ICES), 26504 Rio Patras, Greece.
Laboratory of Pharmaceutical Technology, Dept. of Pharmacy, School of Health Sciences, University of Patras, 26504 Rio Patras, Greece.
Adv Drug Deliv Rev. 2021 Jul;174:53-86. doi: 10.1016/j.addr.2021.01.019. Epub 2021 Feb 2.
Localized or topical administration of drugs may be considered as a potential approach for overcoming the problems caused by the various biological barriers encountered in drug delivery. The combination of using localized administration routes and delivering drugs in nanoparticulate formulations, such as liposomes, may have additional advantages. Such advantages include prolonged retention of high drug loads at the site of action and controlled release of the drug, ensuring prolonged therapeutic effect; decreased potential for side-effects and toxicity (due to the high topical concentrations of drugs); and increased protection of drugs from possible harsh environments at the site of action. The use of targeted liposomal formulations may further potentiate any acquired therapeutic advantages. In this review we present the most advanced cases of localized delivery of liposomal formulations of drugs, which have been investigated pre-clinically and clinically in the last ten years, together with the reported therapeutic advantages, in each case.
局部或局部给药可能被认为是克服药物输送中遇到的各种生物屏障所带来的问题的一种潜在方法。将局部给药途径与纳米颗粒制剂（如脂质体）联合使用可能具有额外的优势。这些优势包括在作用部位长时间保持高药物负荷和药物的控制释放，从而确保长期的治疗效果；降低药物的潜在副作用和毒性（由于药物的高局部浓度）；以及增加对作用部位可能恶劣环境中药物的保护。靶向脂质体制剂的使用可能进一步增强任何获得的治疗优势。在这篇综述中，我们介绍了过去十年中在临床前和临床上研究过的最先进的局部递药脂质体制剂的案例，以及在每种情况下报告的治疗优势。
