雄激素对小鼠中鬼笔环肽诱导的肝毒性的影响。
Effect of androgens on phalloidin-induced liver toxicity in mice.
作者信息
Muraoka Y, Watanabe H, Kometani M, Hasegawa T
机构信息
Shionogi Research Laboratories, Kanzakigawa Laboratory, Osaka, Japan.
出版信息
Toxicol Lett. 1988 Mar;40(3):203-8. doi: 10.1016/0378-4274(88)90042-2.
PMID:3354004
Abstract
A single i.p. dose of phalloidin, 0.75 or 1 mg/kg body weight, induced peliosis hepatis-like lesion (PHLL) at 3 h after injection to mice. Pretreatment with various doses of testosterone propionate for 7 days enhanced phalloidin-induced PHLL. Other anabolic steroids, methyltestosterone, methandriol. fluoxymesterone and oxymetholone had no effect.
摘要
给小鼠腹腔注射一次剂量为0.75或1毫克/千克体重的鬼笔环肽，在注射后3小时可诱发肝紫癜样病变（PHLL）。用不同剂量的丙酸睾酮预处理7天可增强鬼笔环肽诱导的PHLL。其他合成代谢类固醇，如甲基睾酮、美雄醇、氟甲睾酮和羟甲烯龙则无此作用。
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