Matsuda Yohei, Kobayashi Ko, Fukuta Fumimasa, Takayanagi Akio, Hashimoto Kohei, Tanaka Toshiaki, Masumori Naoya
Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Sex Med. 2021 Apr;9(2):100275. doi: 10.1016/j.esxm.2020.10.003. Epub 2021 Feb 1.
Although an association between erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) has been suggested, it was not clarified whether LUTS developed before ED or vice versa.
To clarify whether LUTS develop before ED or vice versa and which symptoms predicted the onset of the other condition in a longitudinal community-based study.
We conducted a longitudinal community-based study on LUTS and ED in aged Japanese men. A follow-up study was conducted to determine their longitudinal changes of LUTS and ED after 15 years. Erectile function was evaluated using a validated questionnaire. LUTS were evaluated based on the International Prostate Symptom Score, quality of life index, and prostate volume.
We evaluated the baseline symptoms among the participants who had LUTS and ED in the follow-up survey and what prior symptoms could predict the onset of the other condition using the data from a long-term longitudinal survey.
A total of 108 men were enrolled in this study. Of the 47 men having both LUTS and ED in the follow-up study, men having only LUTS (n = 16) were more frequent than those having only ED (n = 6) in the initial study. Likewise, of the 38 men having both nocturia and ED at the time of the follow-up study, those having only nocturia (n = 12) were more frequent than those having only ED (n = 5) in the initial study. In multivariable analysis, age 60 years or older (odds ratio: 7.10, 95% CI: 2.09-24.13) and nocturia (odds ratio: 15.83, 95% CI: 3.05-82.15) were independent predictors for the onset of ED.
There were more men with prior onset of LUTS, especially nocturia, than men with prior onset of ED among those with both ED and LUTS in this long-term longitudinal study. Nocturia may be a predictor of subsequent ED. Matsuda Y, Kobayashi K, Fukuta F, et al. Which Happens Earlier, Lower Urinary Tract Symptoms or Erectile Dysfunction?. J Sex Med 2021;9:100275.
尽管已有研究表明勃起功能障碍（ED）与下尿路症状（LUTS）之间存在关联，但尚未明确LUTS是在ED之前出现，还是反之。
在一项基于社区的纵向研究中，明确LUTS是在ED之前出现，还是反之，以及哪些症状可预测另一种情况的发生。
我们对日本老年男性的LUTS和ED进行了一项基于社区的纵向研究。进行了一项随访研究，以确定15年后他们LUTS和ED的纵向变化。使用经过验证的问卷评估勃起功能。基于国际前列腺症状评分、生活质量指数和前列腺体积评估LUTS。
我们在随访调查中评估了患有LUTS和ED的参与者的基线症状，并使用长期纵向调查的数据，分析哪些先前症状可预测另一种情况的发生。
本研究共纳入108名男性。在随访研究中，47名同时患有LUTS和ED的男性中，初始研究时仅患有LUTS的男性（n = 16）比仅患有ED的男性（n = 6）更为常见。同样，在随访研究时同时患有夜尿症和ED的38名男性中，初始研究时仅患有夜尿症的男性（n = 12）比仅患有ED的男性（n = 5）更为常见。在多变量分析中，60岁及以上（比值比：7.10，95%可信区间：2.09 - 24.1）和夜尿症（比值比：15.83，95%可信区间：3.05 - 82.15）是ED发生的独立预测因素。
在这项长期纵向研究中，同时患有ED和LUTS的男性中，先前出现LUTS尤其是夜尿症的男性比先前出现ED的男性更多。夜尿症可能是随后发生ED的一个预测因素。松田洋、小林健、深田丰等。下尿路症状和勃起功能障碍哪个出现更早？。《性医学杂志》2021；9：100275。
