Saravanan Arumugam, Maruthapandi Moorthy, Das Poushali, Luong John H T, Gedanken Aharon
Department of Chemistry, Bar-Ilan Institute for Nanotechnology and Advanced Materials (BINA), Bar-Ilan University, Ramat-Gan 52900, Israel.
School of Chemistry, University College Cork, T12 YN60 Cork, Ireland.
Nanomaterials (Basel). 2021 Feb 2;11(2):369. doi: 10.3390/nano11020369.
Carbon dots (CDs) were obtained from medicinal turmeric leaves () by a facile one-step hydrothermal method and evaluated for their bactericidal activities against two gram-negative; , , and two gram-positive counterparts; , . The CDs exhibited spherical shapes with a mean size of 2.6 nm. The fluorescence spectra of CDs revealed intense fluorescence at λ/ = 362/429 nm with a bright blue color in an aqueous solution. The CDs showed strong photostability under various environmental conditions (pH, salt, and UV-radiation). The complete bactericidal potency of CDs was 0.25 mg/mL for and after 8 h of exposure, while for , and , the CDs at 0.5 mg/mL good antibacterial effect within 8 h and complete eradication after 24 h of exposure is observed. The release of reactive oxygen species played a crucial role in the death of the bacterial cell. The present study provides a strategy for the preparation of CDs from a medicinal plant and their potential antibacterial activities against four common contagious pathogens.
通过简便的一步水热法从药用姜黄叶子中获得了碳点(CDs),并评估了它们对两种革兰氏阴性菌;大肠杆菌、铜绿假单胞菌,以及两种革兰氏阳性菌;金黄色葡萄球菌、枯草芽孢杆菌的杀菌活性。碳点呈现出球形,平均尺寸为2.6纳米。碳点的荧光光谱显示在λ/ = 362/429纳米处有强烈的荧光,在水溶液中呈亮蓝色。碳点在各种环境条件(pH值、盐和紫外线辐射)下表现出很强的光稳定性。对于大肠杆菌和铜绿假单胞菌,碳点在暴露8小时后的完全杀菌效力为0.25毫克/毫升,而对于金黄色葡萄球菌和枯草芽孢杆菌,0.5毫克/毫升的碳点在8小时内具有良好的抗菌效果,在暴露24小时后观察到完全根除。活性氧的释放对细菌细胞的死亡起着关键作用。本研究提供了一种从药用植物制备碳点及其对四种常见传染性病原体潜在抗菌活性的策略。