Holm-Nielsen P, Olsen T S
University Institute of Pathology, Aarhus Kommunehospital, Denmark.
Ultrastruct Pathol. 1988 Jan-Feb;12(1):27-39. doi: 10.3109/01913128809048474.
Renal adenomas, defined as minute cortical foci of proliferating epithelium, are frequently occurring lesions reported to be present in 15%-22% of all adult human kidneys. They can often be found in kidneys with renal cell carcinoma. Their light microscopic structure makes it improbable that they should represent intrarenal metastases. The concept does not include clear cell foci. Ultrastructure of these cortical foci in human kidneys is not well known. A series of 10 intrarenal adenomas in carcinoma-bearing kidneys has been studied using tissue fixed rapidly after nephrectomy by perfusion with 2% glutaraldehyde. The results confirm their tubular origin. Ultrastructural markers of different segments of the nephron were demonstrated. Several of these markers might be present in each single case. The interpretation is that their ultrastructural characteristics do not indicate an origin from a special segment of the nephron. They may reflect an abnormal gene expression associated with the neoplastic change of the cell clone. Some changes are similar to those seen in cells from renal cell carcinoma, although not as prominent as in malignant cells.
肾腺瘤被定义为增殖上皮的微小皮质病灶，是常见病变，据报道在所有成人人肾中占比15%-22%。它们常在患有肾细胞癌的肾脏中被发现。其光镜结构表明它们不太可能是肾内转移瘤。该概念不包括透明细胞病灶。人类肾脏中这些皮质病灶的超微结构尚不清楚。我们使用2%戊二醛灌注肾切除术后快速固定的组织，对一系列10例患癌肾脏中的肾内腺瘤进行了研究。结果证实了它们的肾小管起源。展示了肾单位不同节段的超微结构标志物。每个病例中可能存在几种这些标志物。其解释是，它们的超微结构特征并不表明起源于肾单位的特定节段。它们可能反映了与细胞克隆肿瘤性变化相关的异常基因表达。一些变化与肾细胞癌细胞中所见的变化相似，尽管不如恶性细胞中那么显著。
