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硫酸化乳糖基古菌醇脂质体与不同佐剂联合在小鼠模型中的协同效应

The Synergistic Effects of Sulfated Lactosyl Archaeol Archaeosomes When Combined with Different Adjuvants in a Murine Model.

作者信息

Jia Yimei, Akache Bassel, Agbayani Gerard, Chandan Vandana, Dudani Renu, Harrison Blair A, Deschatelets Lise, Hemraz Usha D, Lam Edmond, Régnier Sophie, Stark Felicity C, Krishnan Lakshmi, McCluskie Michael J

机构信息

Human Health Therapeutics, National Research Council Canada, Ottawa, ON K1A 0R6, Canada.

Aquatic and Crop Resource Development, National Research Council Canada, Montreal, QC H4P 2R2, Canada.

出版信息

Pharmaceutics. 2021 Feb 2;13(2):205. doi: 10.3390/pharmaceutics13020205.

DOI:10.3390/pharmaceutics13020205
PMID:33540932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7913188/
Abstract

Archaeosomes, composed of sulfated lactosyl archaeol (SLA) glycolipids, have been proven to be an effective vaccine adjuvant in multiple preclinical models of infectious disease or cancer. SLA archaeosomes are a promising adjuvant candidate due to their ability to strongly stimulate both humoral and cytotoxic immune responses when simply admixed with an antigen. In the present study, we evaluated whether the adjuvant effects of SLA archaeosomes could be further enhanced when combined with other adjuvants. SLA archaeosomes were co-administered with five different Toll-like Receptor (TLR) agonists or the saponin QS-21 using ovalbumin as a model antigen in mice. Both humoral and cellular immune responses were greatly enhanced compared to either adjuvant alone when SLA archaeosomes were combined with either the TLR3 agonist poly(I:C) or the TLR9 agonist CpG. These results were also confirmed in a separate study using Hepatitis B surface antigen (HBsAg) and support the further evaluation of these adjuvant combinations.

摘要

由硫酸化乳糖基古菌醇（SLA）糖脂组成的古脂质体，已被证明在传染病或癌症的多种临床前模型中是一种有效的疫苗佐剂。SLA古脂质体是一种很有前景的佐剂候选物，因为当它与抗原简单混合时，能够强烈刺激体液免疫和细胞毒性免疫反应。在本研究中，我们评估了SLA古脂质体与其他佐剂联合使用时，其佐剂效果是否能进一步增强。以卵清蛋白为模型抗原，在小鼠中将SLA古脂质体与五种不同的 Toll样受体（TLR）激动剂或皂苷QS-21共同给药。当SLA古脂质体与TLR3激动剂聚肌苷酸-聚胞苷酸（poly(I:C)）或TLR9激动剂CpG联合使用时，与单独使用任何一种佐剂相比，体液免疫和细胞免疫反应均得到极大增强。这些结果在另一项使用乙型肝炎表面抗原（HBsAg）的研究中也得到了证实，并支持对这些佐剂组合进行进一步评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bede/7913188/9305b1c22c22/pharmaceutics-13-00205-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bede/7913188/1e4e03bb68ad/pharmaceutics-13-00205-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bede/7913188/e92225ef5ab5/pharmaceutics-13-00205-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bede/7913188/adeba238c690/pharmaceutics-13-00205-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bede/7913188/6f7eb2c82a9c/pharmaceutics-13-00205-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bede/7913188/46d91df4da38/pharmaceutics-13-00205-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bede/7913188/9305b1c22c22/pharmaceutics-13-00205-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bede/7913188/1e4e03bb68ad/pharmaceutics-13-00205-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bede/7913188/e92225ef5ab5/pharmaceutics-13-00205-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bede/7913188/adeba238c690/pharmaceutics-13-00205-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bede/7913188/6f7eb2c82a9c/pharmaceutics-13-00205-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bede/7913188/46d91df4da38/pharmaceutics-13-00205-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bede/7913188/9305b1c22c22/pharmaceutics-13-00205-g006.jpg

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本文引用的文献

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