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[伴有甲状腺癌和颈部淋巴结结节病的三发性甲状旁腺功能亢进:一例报告]

[Tertiary hyperparathyroidism accompanied with thyroid carcinoma and cervical lymph node sarcoidosis: a case report].

作者信息

Gong Xixiang, Lu Yongxin, Yang Liping, Sun Yang, Li Shihua, Tong Zongwu

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Jan 5;35(1):77-79. doi: 10.13201/j.issn.2096-7993.2021.01.020.

Abstract

A 63-year-old female with 3 years of hemodialysis and 1 year of joint pain was treated with calcimimetics and other drugs for a long time. The bone and joint pain did not improve, and the serum PTH continued to rise. The left thyroid nodule was found during the preoperative localization examination of parathyroid gland. Preoperative examination showed that PTH 1258.9 ng/L, Ca 2.48 mmol/L, P 2.32 mmol/L, ALB 36.70 g/L, ALP 227.00 IU/L. Cervical ultrasonography showed thyroid nodules in the left lobe(TI-RADS 4b), parathyroid hyperplasia and enlargement, and abnormal lymph nodes in the Ⅲ region of the left neck. Postoperative pathology: ①Thyroid papillary carcinoma on the left side, the size of the tumor was about 0.7 cm; ②There were 3 lymph nodes in Ⅲ region, of which 1 showed metastasis, and 1 consistent with sarcoidosis; ③4 parathyroid glands showed proliferative lesions, including the formation of pseudotumor-like nodules on the left upper parathyroid gland with hyperparathyroidism and no cancer invasion; ④There were 6 lymph nodes in the central region, of which 3 showed metastasis; ⑤There was 1 prelaryngeal lymph node and showed metastasis; ⑥There were 8 lymph nodes in Ⅱ region, of which 1 showed metastasis; ⑦There were 21 lymph nodes in Ⅳ region, all of which had no metastasis.

摘要

一名63岁女性,有3年血液透析史及1年关节疼痛史,长期接受拟钙剂及其他药物治疗。骨与关节疼痛未改善,血清甲状旁腺激素(PTH)持续升高。在甲状旁腺术前定位检查时发现左侧甲状腺结节。术前检查显示PTH 1258.9 ng/L,钙2.48 mmol/L,磷2.32 mmol/L,白蛋白36.70 g/L,碱性磷酸酶227.00 IU/L。颈部超声显示左叶甲状腺结节(TI-RADS 4b类)、甲状旁腺增生及肿大,左侧颈部Ⅲ区淋巴结异常。术后病理:①左侧甲状腺乳头状癌,肿瘤大小约0.7 cm;②Ⅲ区有3枚淋巴结,其中1枚有转移,1枚符合结节病;③4枚甲状旁腺呈增生性病变,包括左上甲状旁腺形成假瘤样结节伴甲状旁腺功能亢进,无癌侵犯;④中央区有6枚淋巴结,其中3枚有转移;⑤有1枚喉前淋巴结且有转移;⑥Ⅱ区有8枚淋巴结,其中1枚有转移;⑦Ⅳ区有21枚淋巴结,均无转移。

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