Du Guyu, Tang Jie, Zhang Qian, Ma Xiaojie
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Jan 5;35(1):88-91. doi: 10.13201/j.issn.2096-7993.2021.01.023.
Radiation brain injury（RBI） is one of the complications of radiotherapy for head and neck malignant tumors, which has a serious impact on the prognosis and quality of life of patients. The existence of radiation-induced brain injury not only limits the radiation therapy dose of head and neck malignant tumors, but also restricts the efficacy of tumor patients, and has a serious impact on the prognosis and quality of life of patients. The pathogenesis of radiation-induced brain injury is not yet completely clear, we use various clinical treatment for radiation brain injury patients to alleviate some clinical symptoms, but it cannot effectively reverse the brain injury process. In recent years, with the further exploration of radiation-induced brain injury and the accumulation of clinical experience, studies have found that microglial polarization plays an important role in radiation-induced brain injury, and brain-derived particles can activate microglia. This article reviews the research progress of brain-derived microparticles on the polarization of microglia in radiation-induced brain injury of head and neck tumors.
放射性脑损伤（RBI）是头颈部恶性肿瘤放射治疗的并发症之一，对患者的预后和生活质量有严重影响。放射性脑损伤的存在不仅限制了头颈部恶性肿瘤的放射治疗剂量，还制约了肿瘤患者的疗效，对患者的预后和生活质量产生严重影响。放射性脑损伤的发病机制尚未完全明确，我们采用各种临床治疗方法来缓解放射性脑损伤患者的一些临床症状，但无法有效逆转脑损伤进程。近年来，随着对放射性脑损伤研究的不断深入以及临床经验的积累，研究发现小胶质细胞极化在放射性脑损伤中起重要作用，且脑源性微粒可激活小胶质细胞。本文综述了脑源性微粒对头颈部肿瘤放射性脑损伤中小胶质细胞极化的研究进展。
