Huang Yanran, Wang Ming, Wang Chengshuo, Zhang Luo
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Feb;35(2):185-188. doi: 10.13201/j.issn.2096-7993.2021.02.022.
The pathogenesis of chronic rhinosinusitis（CRS） is closely related to the interactions between the environmental stimuli and the innate defense system. A vast of defensive molecules, such as antimicrobial peptides and proteins（AMPs） could be secreted by the airway epithelial cells and submucosal glands. As an essential component of innate immune system, AMPs are associated with multiple airway disease, such as CRS, chronic obstructive pulmonary disease, bronchiectasis, allergic asthma and so on. AMPs are expressed vastly in nasal mucosa and could exert fundamental antibacterial and inflamatory regulative functions. However, the pathophysiological mechanism of AMPs in CRS is still unclear. What's more, the heterogeneity among studies is relatively high. Thus, the paper was aimed to review the potential function and inflammatory regulation of AMPs in CRS. More rigorous studies with larger samples are needed in the future, to shed light on its possible pathogeneisis mechanisms.
慢性鼻-鼻窦炎（CRS）的发病机制与环境刺激和固有防御系统之间的相互作用密切相关。气道上皮细胞和黏膜下腺体能分泌大量防御分子，如抗菌肽和蛋白质（AMPs）。作为固有免疫系统的重要组成部分，AMPs与多种气道疾病相关，如CRS、慢性阻塞性肺疾病、支气管扩张、过敏性哮喘等。AMPs在鼻黏膜中大量表达，并可发挥基本的抗菌和炎症调节功能。然而，AMPs在CRS中的病理生理机制仍不清楚。此外，各研究之间的异质性相对较高。因此，本文旨在综述AMPs在CRS中的潜在功能和炎症调节作用。未来需要开展更严格、样本量更大的研究，以阐明其可能的发病机制。
