Vera Montenegro Y, Ibarra Velarde F, Quiroz Romero H, Hernández Campos A, Castillo R
Departamento de Parasitología, Facultad de Medicina Veterinaria y Zootecnia, UNAM, CP 04510, Mexico City, Mexico.
Parasitol Res. 2003 Sep;91(1):1-4. doi: 10.1007/s00436-003-0901-y. Epub 2003 Jul 3.
The efficacy of 5-chloro-2-methylthio-6-(1-napthyloxy)-1H-benzimidazole was evaluated with three commercial fasciolicides in terms of the percentage of egg reduction in cattle. Fifty Swiss cows were selected for inclusion in the trial based on finding eggs of Fasciola hepatica in their feces. On day 0, they were blocked in five groups (G) of ten animals each according to fecal egg counts. G1 received compound alpha at 12 mg/kg p.o.; G2 triclabendazole at 12 mg/kg p.o.; G3.closantel at 3.5 mg/kg s.c.; G4 clorsulon at 2.0 mg/kg s.c. G5 animals served as untreated controls. Fecal analysis was performed on days 0, 7, 14, 21, 28, 60 and 90. Efficacy was measured on days 14 and 21. In addition, the extension and intensity effects were determined on day 60. The percentage efficacy for groups 1-4 was 98.1, 98.7, 98.2 and 97.9 on day 14 and 98.5, 97.9, 97.7 and 97.9 on day 21, respectively. No statistical differences were observed between treated groups.
以三种市售抗片形吸虫药为对照，评估了5-氯-2-甲硫基-6-(1-萘氧基)-1H-苯并咪唑对牛的减卵率。根据粪便中发现肝片吸虫卵的情况，挑选了50头瑞士奶牛纳入试验。在第0天，根据粪便虫卵计数将它们分成五组（G组），每组10头动物。G1组口服12mg/kg复方α；G2组口服12mg/kg三氯苯达唑；G3组皮下注射3.5mg/kg氯氰碘柳胺；G4组皮下注射2.0mg/kg氯磺隆。G5组动物作为未治疗对照。在第0、7、14、21、28、60和90天进行粪便分析。在第14天和21天测定疗效。此外，在第60天确定扩展效应和强度效应。第14天，1-4组的疗效百分比分别为98.1%、98.7%、98.2%和97.9%；第21天分别为98.5%、97.9%、97.7%和97.9%。各治疗组之间未观察到统计学差异。
